RO4929097

  • Catalog number
    2011-1
  • Price
    Please ask
  • Size
    1 mg
  • Description
    RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
  • CAS Number
    847925-91-1
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₂H₂₀F₅N₃O₃
  • Molecular Weight
    469.4
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent γ-secretase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24months
  • MDL Number
    MFCD18384976
  • PubChem CID
    49867930
  • SMILES
    CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
  • InChi
    InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25, 26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10, 16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
  • InChi Key
    OJPLJFIFUQPSJR-INIZCTEOSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    RO4929097
  • Alternative name
    RO4929097
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