RO4929097
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Catalog number2011-1
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PricePlease ask
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Size1 mg
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DescriptionRO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.
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CAS Number847925-91-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₂H₂₀F₅N₃O₃
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Molecular Weight469.4
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent γ-secretase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD18384976
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PubChem CID49867930
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SMILESCC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
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InChiInChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25, 26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10, 16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
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InChi KeyOJPLJFIFUQPSJR-INIZCTEOSA-N
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MSDS AvailableYes
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Gene target
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Short nameRO4929097
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Alternative nameRO4929097
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