Cell-permeable. Structurally similar to cyclopamine (Cat. No. 1578). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine (Cat. No. 1893) is a useful negative control.
Is it cell-permeable?
≥98% by TLC
Is this a salt?
Protect from air and moisture
Maximum time for storage
White to off-white solid
DMSO (5 mg/ml) or EtOH (10 mg/ml)
For cells, cell lines and tissues in culture till half confluency.