Human CellExp™ CD3 epsilon (His-tag) & CD3 delta Heterodimer

  • Catalog number
    P1655-50
  • Price
    Please ask
  • Size
    50 µg
  • Synonyms
    Human CellExp™ CD3 delta/epsilon,CD3E & CD3D,Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer,Human CellExp™ CD3 epsilon-CD3 delta Heterodimer,CD3 d/e,CD3 delta/epsilon,Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer,CD3 delta & CD3 epsilon,CD3 epsilon (His-tag) - CD3 delta Heterodimer
  • Alternative_names
    Human CellExp™ CD3 delta/epsilon,CD3E & CD3D,Human CellExp™ CD3 epsilon (His-tag) - CD3 delta Heterodimer,Human CellExp™ CD3 epsilon-CD3 delta Heterodimer,CD3 d/e,CD3 delta/epsilon,Human CellExp™ CD3 epsilon (His-tag) CD3 delta Heterodimer,CD3 delta & CD3 epsilon,CD3 epsilon (His-tag) - CD3 delta Heterodimer
  • Description
    CD3 epsilon (his-tag) and CD3 delta heterodimer important in coupling antigen recognition
  • Recombinant
    1
  • Source
    HEK 293 cells
  • Purity by SDS PAGE
    ≥ 95% by SDS-PAGE
  • Molecular Weight
    The calculated MW is 16 kDa (CD3E) and 13 kDa (CD3D)
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized powder
  • Physical form description
    Lyophilized
  • Reconstitution Instructions
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Reconstitute in sterile PBS (pH 7.4).
  • Background Information
    T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3E, CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta, and gamma/delta heterodimers, form the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Since CD3 is required for T-Cell activation, drugs and therapeutics targeting CD3 are being researched for diseases like Type 1 diabetes and other autoimmune diseases. For example, Muromonab-CD3, a monoclonal antibody targeting the CD3 receptor, is an immunosuppressant drug to reduce acute rejection in patients with organ transplants.
  • Amino acid sequence
    Human CD3E (Asp 23 - Asp 126) (6x His-tag at C-Terminal) and CD3D (Phe 22 - Ala 105, no His-tag)
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Conjugation
    histidine
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
  • Short name
    CellExp™ CD3 epsilon (His-tag) & CD3 delta Heterodimer
  • Technique
    Tags
  • Label
    His
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ CD3 epsilon (histidine-detection labelled) & CD3 delta Heterodimer
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