Stat3 Peptide Inhibitor, Cell-Permeable

  • Catalog number
    1778-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    PY*LKTK-mts (where Y* = phosphotyrosine)
  • Description
    Cell-permeable. A peptide-based inhibitor, PY*LKTK-mts (mts = membrane translocating sequence) that selectively inhibits constitutive and ligand-induced activation of Stat3 in vivo. Also suppresses transformation by Src oncoprotein that requires constitutive Stat3 activation.
  • Structure Available
    No
  • Peptide sequence
    H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH. CF3CO2H
  • Salt Form
    Yes
  • Molecular Formula
    C₉₂H₁₅₇N₂₀O₂₄P .C₂HF₃O₂
  • Molecular Weight
    1958.32 . 114.02
  • Cell Permeable
    Yes
  • Purity
    ≥95% by HPLC
  • Solubilities
    H₂O
  • Handling
    Protect from air and moisture
  • Tag Line
    A Stat3 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    48 months
  • SMILES
    N/A
  • InChi
    N/A
  • InChi Key
    N/A
  • MSDS Available
    Yes
  • Additional description
    For cells, cell lines and tissues in culture till half confluency. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
  • Gene target
  • Short name
    Stat3 Peptide Inhibitor, -Permeable
  • Technique
    peptide, peptides
  • Alternative name
    signal transducer and activator on transcription 3 (acute-phase response factor) short protein sequence suppressor, cellular-Permeable
  • Alternative technique
    peptides
  • Alternative to gene target
    signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541
  • Tissue
    cell
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