Entrectinib

  • Catalog number
    B1324-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    (Z)-N-(5-(3,5-difluorobenzyl)-1H-indazol-3(2H)-ylidene)-4-(4-methylpiperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide
  • Description
    Entrectinib is an inhibitor of TrkA (IC₅₀ = 1.7 nM), TrkB (IC₅₀ = 0.1 nM), and TrkC (IC₅₀ = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC₅₀ = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC₅₀ = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations, and inhibits ALK‐dependent signaling
  • CAS Number
    1108743-60-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₃₁H₃₄F₂N₆O₂
  • Molecular Weight
    560.64
  • Cell Permeable
    Yes
  • Purity
    ≥97% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A tyrosine kinase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    25141092
  • SMILES
    N1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
  • InChi
    InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
  • InChi Key
    HAYYBYPASCDWEQ-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Entrectinib
  • Alternative name
    Entrectinib
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