Okadaic acid, PP1 and PP2A inhibitor

  • Catalog number
    SIH-521-100UG
  • Price
    Please ask
  • Size
    100 µg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    78111-17-8
  • Description
    PP1 and PP2A inhibitor
  • Molecular weight
    805 g/mol
  • Primary research fields
    Cell Signaling
  • Other name
    9,10-Deepithio-9,10-didehydroacanthifolicin
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C44H68O13
  • Origin
    Synthetic
  • Purity pourcentage
    ≥98% (HPLC)
  • Soluble in
    Soluble in chloroform, ethanol, methanol, acetone or ethyl acetate
  • Physical appearance
    White crystalline solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H315 Causes skin irritation Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P361 Remove/Take off immediately all contaminated clothing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
  • PubChem number
    446512
  • Scientific context
    Okadaic acid is a potent and selective inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible inhibitor.
  • Bibliography
    1. Cohen P., Holmes C.F., & Tsukitani Y. (1990) Trends Biochem. 15(3): 98–102.
  • Release date
    1-Oct-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Okadaic acid (SIH-521), a PP1 and PP2A inhibitor. CAS #: 78111-17-8. Molecular Formula: C44H68O13. Molecular Weight: 805 g/mol. Chemical structure of Okadaic acid, a PP1 and PP2A inhibitor (SIH-521). CAS # 78111-17-8. Molecular Formula: C44H68O13.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.0001
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
    Okadaic   acid   PP1   PP2A   inhibitor  
  • Gene symbol
    PPP2R1B, NPY4R, PPP2R1A, PPA1
  • Short name
    Okadaic acid, PP1 PP2A inhibitor
  • Alternative name
    Okadaic acid, PP1 and PP2A suppressor
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