LY-411575
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Catalog number2648-1
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PricePlease ask
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Size1 mg
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Alternative_nameN2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide; LSN-411575
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DescriptionLY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and recovery of hearing in mice after acoustic trauma.
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CAS Number209984-57-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₆H₂₃F₂N₃O₄
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Molecular Weight479.48
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~ 5 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent γ-secretase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life48 months
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PubChem CID10435235
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SMILESCC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
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InChiInChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
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InChi KeyULSSJYNJIZWPSB-CVRXJBIPSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolARHGDIB
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Short nameLY-411575
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Alternative nameLY-411575
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Gene info
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Identity
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Gene
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Long gene nameRho GDP dissociation inhibitor beta
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Synonyms gene
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Synonyms gene name
- Rho GDP dissociation inhibitor (GDI) beta
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-08-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- Minor histocompatibility antigens
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VEGA ID