LY-411575

  • Catalog number
    2648-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide; LSN-411575
  • Description
    LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and recovery of hearing in mice after acoustic trauma.
  • CAS Number
    209984-57-6
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₆H₂₃F₂N₃O₄
  • Molecular Weight
    479.48
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (~ 5 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent γ-secretase inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    48 months
  • PubChem CID
    10435235
  • SMILES
    CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
  • InChi
    InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
  • InChi Key
    ULSSJYNJIZWPSB-CVRXJBIPSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    ARHGDIB
  • Short name
    LY-411575
  • Alternative name
    LY-411575
Gene info
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