PHGDH Antibody, ALEXA FLUOR 594
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Catalog numberbs-2970R-A594
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PricePlease ask
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Size100ul
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Long namePHGDH Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known asAnti-PHGDH PAb ALEXA FLUOR 594
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 594
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenPHGDH
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SpecificityThis is a highly specific antibody against PHGDH.
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ModificationUnmodified
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Modification SiteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range120-160/533
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Subcellular locationIntracellular
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PHGDH
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Gene ID Number26227
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Swiss ProtO43175
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenThe survival and development of central neurons require the supply of trophic factors by glial cells. The trophic actions of glial cells on Purkinje neurons are mediated by L-serine and glycine, which are glia-derived trophic factors synthesized by 3PGDH (1). 3PGDH protein is 544 amino acids in length. Two distinct mRNA transcripts that encode for 3PGDH protein in normal human tissues are dominant 2.1 kb mRNA, which is highly expressed in prostate, testis, ovary, brain, liver, kidney, and pancreas, and weakly expressed in thymus, colon, and heart, and 710 bp mRNA, which is highly expressed in heart and skeletal muscle (2). 3PGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status (2). 3PGDH protein is also highly expressed in adult and fetal brain tissues (3). 3PGDH protein plays an important role in the metabolism, development, and function of the central nervous system (3) and its deficiency is a treatable congential error (4-5) that impairs L-serine biosynthesis which is characterized by congenital microcephaly, psychomotor retardation, and seizures (3).
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission590nm/617nm
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SynonymsNLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113; D-3-phosphoglycerate dehydrogenase; PHGDH; PGDH3
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PropertiesFor facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR® 594
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ConjugatedAlexa conjugate 1
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French translationanticorps
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Gene target
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Gene symbolPHGDH
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Short nameAnti-PHGDH
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 594
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Alternative namePHGDH Polyclonal Antibody, ALEXA FLUOR 594
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namephosphoglycerate dehydrogenase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-11-22
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data