SB203580, p38 MAP kinase inhibitor

• Catalog number
  SIH-474-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  152121-47-6
• Description
  p38 MAP kinase inhibitor
• Molecular weight
  377,4 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C21H16FN3OS
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (HPLC)
• Soluble in
  Soluble in DMSO (50 mg/ml)
• Physical appearance
  White to off-white powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H318 Causes serious eye damage. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously wit h water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/ physician. P330 Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant
• PubChem number
  176155
• Scientific context
  SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.
• Bibliography
  1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of SB203580 (SIH-474), a p38 MAP kinase inhibitor. CAS #: 152121-47-6. Molecular Formula: C21H16FN3OS. Molecular Weight: 377.4 g/mol. Chemical structure of SB203580, a p38 MAP kinase inhibitor (SIH-474). CAS # 152121-47-6. Molecular Formula: C21H16FN3OS.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SB203580   p38   MAP   kinase   inhibitor  
• Gene symbol
  MOAP1, MAP7, MASP2, MASP1
• Short name
  SB203580, p38 MAP kinase inhibitor
• Alternative name
  SB203580, p38 mitogen-stimulated protein kinase phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:16658
• Gene
  MOAP1
• Long gene name
  modulator of apoptosis 1
• Synonyms
  • MAP-1
  • PNMA4
• Synonyms name
  • paraneoplastic Ma antigen family member 4
• GenBank acession
  • BC015044
• Locus
  14q32.12
• Discovery year
  2002-11-13
• Entrez gene record
  64112
• Pubmed identfication
  • 11060313
• Classification
  • Paraneoplastic Ma antigens
• VEGA ID
  OTTHUMG00000169184

Gene info

• Identity
  HGNC:6869
• Gene
  MAP7
• Long gene name
  microtubule associated protein 7
• Synonyms
  • E-MAP-115
• Synonyms name
  • ensconsin
• GenBank acession
  • X73882
• Locus
  6q23.3
• Discovery year
  1999-01-22
• Entrez gene record
  9053
• Pubmed identfication
  • 8408219
• RefSeq identity
  • NM_003980
• VEGA ID
  OTTHUMG00000015646

Gene info

• Identity
  HGNC:6902
• Gene
  MASP2
• Long gene name
  MBL associated serine protease 2
• Synonyms gene
  • MASP1P1
• Synonyms gene name
  • mannan-binding lectin serine protease 2
  • mannan-binding lectin serine peptidase 1 pseudogene 1
  • mannan-binding lectin serine protease 1 pseudogene 1
• Synonyms
  • Map19
  • sMAP
  • MAP-2
• Synonyms name
  • mannose-binding lectin-associated serine protease 2
  • mannose-binding lectin associated protein 19
• GenBank acession
  • X98400
• Locus
  1p36.22
• Discovery year
  1998-12-17
• Entrez gene record
  10747
• Pubmed identfication
  • 9087411
  • 9777418
• RefSeq identity
  • NM_006610
• Classification
  • Sushi domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000002121
• Locus Specific Databases
  • MASP2base: Mutation registry for MASP-2 deficiency
  • LRG_82

Gene info

• Identity
  HGNC:6901
• Gene
  MASP1
• Long gene name
  MBL associated serine protease 1
• Synonyms gene
  • CRARF
  • PRSS5
• Synonyms gene name
  • mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan binding lectin serine peptidase 1
• Synonyms
  • MASP
  • Map44
  • MASP-3
  • MAP-1
• Synonyms name
  • C4/C2 activating component of Ra-reactive factor
  • mannose-binding lectin-associated serine protease 1
• GenBank acession
  • D28593
• Locus
  3q27.3
• Discovery year
  1995-07-06
• Entrez gene record
  5648
• Pubmed identfication
  • 8018603
  • 8240317
• RefSeq identity
  • NM_001879
• Classification
  • Serine proteases
  • Complement system activation components
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000156461
• Locus Specific Databases
  • LRG_349

Similar products