Aftin-5

  • Catalog number
    2575-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    (2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidβ Forty-Two Inducer 5
  • Description
    Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
  • Structure Available
    Y
  • Salt Form
    No
  • Molecular Formula
    C₁₉H₂₆N₆O
  • Molecular Weight
    354.45
  • Cell Permeable
    Yes
  • Purity
    ≥98% by NMR
  • Solubilities
    DMSO or EtOH
  • Handling
    Protect from air and light
  • Tag Line
    An amyloid-β42 Inducer
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    24 months
  • SMILES
    CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)C3=CC=CC=C3)=C2N=C1
  • InChi
    InChI=1S/C19H26N6O/c1-5-14(11-26)21-19-22-17(24(4)15-9-7-6-8-10-15)16-18(23-19)25(12-20-16)13(2)3/h6-10,12-14,26H,5,11H2,1-4H3,(H,21,22,23)/t14-/m1/s1
  • InChi Key
    HYFZLABHJHEEFS-CQSZACIVSA-N
  • MSDS Available
    Yes
  • Gene target
    Aftin-5  
  • Short name
    Aftin-5
  • Alternative name
    Aftin-5
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