EN2/Engrailed 2 Antibody, ALEXA FLUOR 594
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Catalog number
bs-11552R-A594
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Price
Please ask
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Size
100ul
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Long name
EN2/Engrailed 2 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
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Also known as
Anti-EN2/Engrailed 2 PAb ALEXA FLUOR 594
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 594
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
EN2/Engrailed 2
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Specificity
This is a highly specific antibody against EN2/Engrailed 2.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Immunogen range
300-333/333
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Subcellular location
Nucleus
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EN2/Engrailed 2
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Gene ID Number
2020
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Swiss Prot
P19622
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
The engrailed-2 gene, EN2, a murine homolog of the Drosophila homeobox gene engrailed (EN), is required for midbrain and cerebellum development and dorsal/ventral patterning of the limbs as well as apical ectodermal ridge formation. In Drosophila, the EN gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Human EN-1 and EN-2 are homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. Different mutations in the mouse homologs, EN-1 and EN-2, produce different developmental defects that frequently are lethal. EN-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum. EN-1 and EN-2 regulate expression of a-synuclein, a gene that is genetically linked to Parkinson’s disease. During early brain development mouse EN-2 is expressed in a broad band across most of the mid-hindbrain region. EN-2 is also expressed in mouse myoblasts and has been assiciated with cerebellar hypoplasia.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
590nm/617nm
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Synonyms
Homeobox protein engrailed-2; Homeobox protein en-2; Hu-En-2; EN2
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Properties
For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR® 594
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Conjugated
Alexa conjugate 1
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French translation
anticorps
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Gene target
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Gene symbol
EN2, EN2-DT
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Short name
Anti-EN2/Engrailed 2
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 594
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Alternative name
EN2/Engrailed 2 Polyclonal Antibody, ALEXA FLUOR 594
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
engrailed homeobox 2
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Locus
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Discovery year
1988-08-31
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Entrez gene record
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RefSeq identity
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Classification
- NKL subclass homeoboxes and pseudogenes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
EN2 divergent transcript
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Locus
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Discovery year
2021-06-30
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Classification
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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