Nuclear Factor Kappa B (NFkB) Polyclonal Antibody (Human, Mouse)

• Catalog number
  PAB824Mu01-1ml
• Price
  Please ask
• Size
  1ml

• Description
  A Rabbit polyclonal antibody against Human, Mouse Nuclear Factor Kappa B (NFkB)
• Specifications
  Host: Rabbit; Species Reactivity: Human, Mouse; Clonality: polyclonal; Tested applications: WB, IHC; Concentration: 500ug/ml; Isotype: IgG; Conjugation: Unconjugated
• Additional_information
  Sequence of the immunogen: NFkB (Pro40~Met365); Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
• Storage_and_shipping
  Upon receipt, store at -20°C or -80°C. Prepare working aliqotes prior to storage to avoid repeated freeze-thaw cycles.
• Notes
  Research Use Only.
• Properties
  If you buy Antibodies supplied by Cloud Clone Corp they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Gene
  NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  Factor   Kappa   NFkB  
• Gene symbol
  NFKBIB, NFKBIE, NFKB1
• Short name
  Factor Kappa B (NFkB) Polyclonal Antibody ( , Mouse)
• Technique
  Polyclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, mouses, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Host
  mouse
• Species
  Mouse, Humans, Mouses
• Alternative name
  Nuclear Factor Kappa B (NFkB) polyclonal (antibody to-) (H. sapiens, Mouse)
• Alternative technique
  polyclonals, antibodies, murine

Gene info

• Identity
  HGNC:7798
• Gene
  NFKBIB
• Long gene name
  NFKB inhibitor beta
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
• Synonyms
  • IKBB
  • TRIP9
• Synonyms name
  • NF-kappa-B inhibitor beta
• GenBank acession
  • L40407
• Locus
  19q13.2
• Discovery year
  1997-07-01
• Entrez gene record
  4793
• Pubmed identfication
  • 9763672
• RefSeq identity
  • NM_002503
• Classification
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000177631

Gene info

• Identity
  HGNC:7799
• Gene
  NFKBIE
• Long gene name
  NFKB inhibitor epsilon
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
• Synonyms
  • IKBE
• Synonyms name
  • NF-kappa-B inhibitor epsilon
• GenBank acession
  • U91616
• Locus
  6p21.1
• Discovery year
  1997-07-01
• Entrez gene record
  4794
• Pubmed identfication
  • 9135156
• Classification
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000014762

Gene info

• Identity
  HGNC:7794
• Gene
  NFKB1
• Long gene name
  nuclear factor kappa B subunit 1
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
• Synonyms
  • KBF1
  • p105
  • NFKB-p50
  • p50
  • NF-kappaB
  • NFkappaB
  • NF-kB1
• Synonyms name
  • Nuclear factor NF-kappa-B p105 subunit
• GenBank acession
  • M58603
• Locus
  4q24
• Discovery year
  1991-11-14
• Entrez gene record
  4790
• Pubmed identfication
  • 1992489
• RefSeq identity
  • NM_003998
• Classification
  • NF-kappa B complex subunits
  • Ankyrin repeat domain containing
  • IPT domain containing
• VEGA ID
  OTTHUMG00000161080
• Locus Specific Databases
  • LRG_1316

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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