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FGFR2 Antibody

FGFR2 Antibody is available 1 time from Bioss primary unconjugated antibodies labs

bs-0675R | FGFR2 Antibody size: 0.1ml | 299.16 USD

Catalog number bs-0675R
Price 299.16 USD
Size 0.1ml
1. Gene info
Identity 3689
Gene FGFR2
Long gene name fibroblast growth factor receptor 2
Synonyms gene
  • KGFR
  • BEK
  • CFD1
  • JWS
Synonyms gene name
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • craniofacial dysostosis 1
  • Jackson-Weiss syndrome
Synonyms
  • CEK3
  • TK14
  • TK25
  • ECT1
  • K-SAM
  • CD332
Synonyms name
  • Crouzon syndrome
  • Pfeiffer syndrome
GenBank acession
  • AK026508
Locus 10q26.13
Discovery year 1991-05-09
Entrez gene record 2263
RefSeq identity
  • NM_022976
  • NM_000141
Classification
  • CD molecules
  • Receptor tyrosine kinases
  • I-set domain containing
Havana BLAST/BLAT OTTHUMG00000019175
Locus Specific Databases
  • LRG_994
Product images
    #.pngImage was kindly submitted by Dr. Uthaman from Yale University. L6 cells were transfected with FGFR2, and stained with RABBIT ANTI-FGFR2 POLYCLONAL ANTIBODY, conjugated (bs-0675R-FITC) at 1:100 dilution\\nParaformaldehyde-fixed, paraffin embedded human skin; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Paraformaldehyde-fixed, paraffin embedded human stomach cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C f
Product files
Long name FGFR2 Primary Polyclonal Antibody
Also known as FGFR2 PAb
Category Primary Antibodies
Conjugation Unconjugated
Target Antigen FGFR2
Specificity This is a highly specific antibody against FGFR2.
Modification(s) None
Modification site(s) Unmodified antibody
Clonality Polyclonal antibody
Clone number Polyclonal antibody
Concentration 1ug per 1ul
Subcellular location Extracellular
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR2
Gene ID number 2263
Swiss Prot P21802
Tested Applications FCM, IHC-P
Recommended dilutions FCM(1:20-100), IHC-P(1:100-500)
Cross reactivity Human, Mouse, Rat
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Purification method This antibody was purified via Protein A.
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Fibroblast growth factor receptor 2; FGFR-2; Keratinocyte growth factor receptor; FGFR2; KSAM
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetFGFR2
Short name Anti-FGFR2
Technique Antibody
Host Rabbit (Oryctolagus cuniculus)
Isotype Immunoglobulin G (IgG)
Alternative name FGFR2 Polyclonal Antibody
Alternative technique antibodies
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