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FGFR2 Antibody

FGFR2 Antibody is available 1 time from Bioss primary unconjugated antibodies labs

bs-0675R | FGFR2 Antibody size: 0.1ml | 291.30 USD

Catalog number bs-0675R
Price 291.30 USD
Size 0.1ml
1. Gene info
Identity3689
GeneFGFR2
Synonyms gene
Synonyms gene name
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • craniofacial dysostosis 1
  • Jackson-Weiss syndrome
GenBank acession
Discovery year1991-05-09
RefSeq identity
Havana BLAST/BLAT OTTHUMG00000019175
Locus Specific Databases
  • LRG_994
2. Gene info
Identity6208
GeneJWS
Synonyms gene
Synonyms gene name
  • bacteria-expressed kinase
  • keratinocyte growth factor receptor
  • craniofacial dysostosis 1
  • Jackson-Weiss syndrome
GenBank acession
Discovery year1991-05-09
RefSeq identity
Havana BLAST/BLAT OTTHUMG00000019175
Locus Specific Databases
  • LRG_994
MeSH Data
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    #.png
Product files
Synonym names BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Fibroblast growth factor receptor 2; FGFR-2; Keratinocyte growth factor receptor; FGFR2; KSAM
Clonality Polyclonal antibody
Category Primary Antibodies
Also known as FGFR2 PAb
Modification(s) None
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR2
Cross reactivity Human, Mouse, Rat
Swiss Prot P21802
Specificity This is a highly specific antibody against FGFR2.
Long name FGFR2 Primary Polyclonal Antibody
Subcellular location Extracellular
Gene ID number 2263
Tested Applications FCM, IHC-P
Recommended dilutions FCM(1:20-100), IHC-P(1:100-500)
Modification site(s) Unmodified antibody
Background of the target antigen Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Concentration 1ug per 1ul
Purification method This antibody was purified via Protein A.
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Target Antigen FGFR2
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Conjugation Unconjugated
Clone number Polyclonal antibody
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetFGFR2
Short name FGFR2 Antibody
Technique Antibody
Alternative name FGFR2 (Antibody to)
Alternative technique antibodies
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