Carfilzomib, 20S Proteasome inhibitor

• Catalog number
  SIH-544-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  868540-17-4
• Description
  20S Proteasome inhibitor
• Molecular weight
  719,9 g/mol
• Primary research fields
  Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
• Other name
  (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, PR-17, Carfilzomib, Kyprolis, Carfilzomib (PR-171), PR-171, UNII-72X6E3J5AR
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C40H57N5O7
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  Soluble in DMSO (80 mg/ml), or ethanol (25 mg/ml)
• Physical appearance
  White powder
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• PubChem number
  11556711
• Scientific context
  Carfilzomib / PR-17 is an irreversible proteasome inhibitor that targets the chymotrypsin-like beta5 subunit of 20S proteasome. It can arrest the cell cycle and trigger apoptosis in tumor cell lines.
• Release date
  30/Aug/2016
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Carfilzomib (SIH-544), a 20S Proteasome inhibitor. CAS #: 868540-17-4. Molecular Formula: C40H57N5O7. Molecular Weight: 719.9 g/mol. Chemical structure of Carfilzomib, a 20S Proteasome inhibitor (SIH-544). CAS # 868540-17-4. Molecular Formula: C40H57N5O7.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Carfilzomib   20S   Proteasome   inhibitor  
• Short name
  Carfilzomib, 20S Proteasome inhibitor
• Alternative name
  Carfilzomib, 20S protein degradation aggregate suppressor

Similar products