MS-275 (Entinostat, SNDX-275)

Alternative_name

Entinostat, SNDX-275
Description

Preferentially inhibits HDAC1 (IC₅₀ = 300 nM) over HDAC3 (IC₅₀ = 8 µM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 µM).
CAS Number

209783-80-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₂₀N₄O₃
Molecular Weight

376.41
Cell Permeable

Yes
Purity

≥99% by HPLC
Solubilities

DMSO (38 mg/ml)
Handling

Protect from light and moisture
Tag Line

A HDAC1 and HDAC3 inhibitor
Storage Condition

-20°C
Shipping Condition

RT
Shelf Life

24months
MDL Number

MFCD08272435
PubChem CID

4261
PubChem CID Link
SMILES

C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
InChi

InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13- 24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChi Key

INVTYAOGFAGBOE-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes