GDC-0068

  • Catalog number
    2667-1
  • Price
    Please ask
  • Size
    1 mg
  • Alternative_name
    (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one
  • Description
    GDC-0068 is a potent, ATP-competitive, pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Displays selectivity over more than other 200 screened kinases. Potential anticancer agent.
  • CAS Number
    1001264-89-6
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₄H₃₂ClN₅O₂
  • Molecular Weight
    458
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>50 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent pan-Akt inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    24788740
  • SMILES
    CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
  • InChi
    nChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
  • InChi Key
    GRZXWCHAXNAUHY-NSISKUIASA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    GDC-0068
  • Alternative name
    GDC-0068
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