GDC-0068
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Catalog number2667-1
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PricePlease ask
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Size1 mg
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Alternative_name(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one
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DescriptionGDC-0068 is a potent, ATP-competitive, pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Displays selectivity over more than other 200 screened kinases. Potential anticancer agent.
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CAS Number1001264-89-6
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₃₂ClN₅O₂
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Molecular Weight458
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>50 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent pan-Akt inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID24788740
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SMILESCC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
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InChinChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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InChi KeyGRZXWCHAXNAUHY-NSISKUIASA-N
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MSDS AvailableYes
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Gene target
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Short nameGDC-0068
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Alternative nameGDC-0068
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