Recombinant Mouse C-C Motif Chemokine 3/CCL3/MIP-1aProtein(N-6His) 50µg

• Catalog number
  PKSM040982-50µg
• Price
  Please ask
• Size
  50µg

• Activity
  NA
• Synonym
  C-C motif chemokine 3;Heparin-binding chemotaxis protein; Macrophage inflammatory protein 1-alpha;MIP1-a; chemokine (C-C motif) ligand 3; LD78a; LD78 alpha; MIP-1 alpha;Scya3
• Sequence
  Ala24-Ala92
• Fusion tag
  N-6His
• Accession
  P10855
• Expressed Host
  E.coli
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  10.8 kDa
• AP Mol Mass
  15 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,5%Trehalose,1mM EDTA,pH8.0.
• Background
  C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, smooth muscle cells, and epithelial cells. Mature mouse CCL3 shares 73%, 91%, and 82% amino acid sequence identity with human, rat, and cotton rat CCL3, respectively. CCL3 exerts its biological functions through interactions with CCR1, CCR3, and CCR5. It is cleared from the extracellular space by internalization via the decoy chemokine receptor D6. CCL3 promotes the chemoattraction, adhesion to activated vascular endothelium, and cellular activation of many hematopoietic cell types including activated T cells, NK cells, neutrophils, monocytes, immature dendritic cells, and eosinophils. CCL3 is also known as stem cell inhibitor (SCI) and can inhibit the proliferation of hematopoietic progenitor cells. CCL3 bioactivity contributes to tumor metastasis and the inflammatory components of viral infection, rheumatoid arthritis, and hepatitis, although it also can suppress the replication of HIV.
• Technical data
• Description
  Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by Elabscience in 1.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  C-C   Motif   Chemokine   3/CCL3/MIP-1aProtein   N-6His   50µg  
• Gene symbol
  CCL3, MIPEP, SMC4, TNPO1, MIP, CCL26, MYB, PCK1, SFTPC, VCX3B
• Short name
  Recombinant Mouse C-C Motif Chemokine 3/CCL3/MIP-1aProtein(N-6His) 50µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse C-C Motif Chemokine 3/chemokine (C-C motif) ligand 3/MIP-1aProtein(N-6His) 50µg
• Alternative technique
  rec, murine
• Alternative to gene target
  chemokine (C-C motif) ligand 3, G0S19-1 and LD78ALPHA and MIP-1-alpha and MIP1A and SCYA3, CCL3 and IDBG-776925 and ENSG00000277632 and 6348, identical protein binding, Extracellular

Gene info

• Identity
  HGNC:10627
• Gene
  CCL3
• Long gene name
  C-C motif chemokine ligand 3
• Synonyms gene
  • SCYA3
• Synonyms gene name
  • small inducible cytokine A3 (homologous to mouse Mip-1a)
  • chemokine (C-C motif) ligand 3
• Synonyms
  • G0S19-1
  • LD78ALPHA
  • MIP-1-alpha
• GenBank acession
  • M23178
• Locus
  17q12
• Discovery year
  1990-07-05
• Entrez gene record
  6348
• RefSeq identity
  • NM_002983
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000188413

Gene info

• Identity
  HGNC:7104
• Gene
  MIPEP
• Long gene name
  mitochondrial intermediate peptidase
• Synonyms
  • MIP
• Locus
  13q12.12
• Discovery year
  1996-10-30
• Entrez gene record
  4285
• Pubmed identfication
  • 9073519
  • 33669127
• Classification
  • M3 metallopeptidase family
• VEGA ID
  OTTHUMG00000016573

Gene info

• Identity
  HGNC:14013
• Gene
  SMC4
• Long gene name
  structural maintenance of chromosomes 4
• Synonyms gene
  • SMC4L1
• Synonyms gene name
  • SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
  • SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
• Synonyms
  • hCAP-C
  • CAP-C
• GenBank acession
  • AF092564
• Locus
  3q25.33
• Discovery year
  2001-02-22
• Entrez gene record
  10051
• Pubmed identfication
  • 9789013
  • 10319587
• Classification
  • Structural maintenance of chromosomes proteins
  • Condensin I subunits
  • Condensin II subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000159006

Gene info

• Identity
  HGNC:6401
• Gene
  TNPO1
• Long gene name
  transportin 1
• Synonyms gene
  • KPNB2
• Synonyms gene name
  • karyopherin (importin) beta 2
• Synonyms
  • MIP
  • TRN
  • IPO2
  • MIP1
• Synonyms name
  • importin 2
• GenBank acession
  • U70322
• Locus
  5q13.2
• Discovery year
  1997-04-21
• Entrez gene record
  3842
• Pubmed identfication
  • 8808633
  • 9144189
• RefSeq identity
  • NM_002270
• Classification
  • Importins
  • Armadillo like helical domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000100967

Gene info

• Identity
  HGNC:7103
• Gene
  MIP
• Long gene name
  major intrinsic protein of lens fiber
• Synonyms
  • MP26
  • LIM1
  • AQP0
• Synonyms name
  • aquaporin 0
• Locus
  12q13.3
• Discovery year
  2001-06-22
• Entrez gene record
  4284
• Pubmed identfication
  • 1840563
  • 7536742
• RefSeq identity
  • NM_012064
• Classification
  • Aquaporins
• VEGA ID
  OTTHUMG00000170571
• Locus Specific Databases
  • LRG_1291

Gene info

• Identity
  HGNC:10625
• Gene
  CCL26
• Long gene name
  C-C motif chemokine ligand 26
• Synonyms gene
  • SCYA26
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 26
  • chemokine (C-C motif) ligand 26
• Synonyms
  • MIP-4alpha
  • eotaxin-3
  • IMAC
  • MIP-4a
  • TSC-1
• Synonyms name
  • macrophage inflammatory protein 4-alpha
  • small inducible cytokine A26
  • CC chemokine IMAC
  • chemokine N1
  • thymic stroma chemokine-1
  • eotaxin-3
• GenBank acession
  • AF124601
• Locus
  7q11.23
• Discovery year
  1999-06-09
• Entrez gene record
  10344
• Pubmed identfication
  • 10373330
• RefSeq identity
  • NM_006072
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130403

Gene info

• Identity
  HGNC:7545
• Gene
  MYB
• Long gene name
  MYB proto-oncogene, transcription factor
• Synonyms gene name
  • v-myb avian myeloblastosis viral oncogene homolog
• Synonyms
  • c-myb
• Locus
  6q23.3
• Discovery year
  2001-06-22
• Entrez gene record
  4602
• Pubmed identfication
  • 17599807
• Classification
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000015629
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:8724
• Gene
  PCK1
• Long gene name
  phosphoenolpyruvate carboxykinase 1
• Synonyms gene name
  • phosphoenolpyruvate carboxykinase 1 (soluble)
• Synonyms
  • PEPCK-C
• Locus
  20q13.31
• Discovery year
  1990-09-10
• Entrez gene record
  5105
• Pubmed identfication
  • 1492743
• VEGA ID
  OTTHUMG00000032825

Gene info

• Identity
  HGNC:10802
• Gene
  SFTPC
• Long gene name
  surfactant protein C
• Synonyms gene
  • SFTP2
• Synonyms gene name
  • surfactant, pulmonary-associated protein C
• Synonyms
  • SP-C
  • PSP-C
  • SMDP2
  • BRICD6
• Synonyms name
  • BRICHOS domain containing 6
• Locus
  8p21.3
• Discovery year
  1988-05-11
• Entrez gene record
  6440
• Pubmed identfication
  • 1859376
  • 16709565
• RefSeq identity
  • NM_003018
• Classification
  • BRICHOS domain containing
• VEGA ID
  OTTHUMG00000163775

Gene info

• Identity
  HGNC:31838
• Gene
  VCX3B
• Long gene name
  variable charge X-linked 3B
• Synonyms
  • VCX-C
• Locus
  Xp22.31
• Discovery year
  2005-01-11
• Classification
  • Variable charge X/Y family
• VEGA ID
  OTTHUMG00000021106

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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