Human CellExp™ BMP-2, Human Recombinant
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Catalog number6444-10
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PricePlease ask
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Size10 ug
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SynonymsHuman Cellexp Human Recombinant BMP-2
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Alternative_namesBMP-2, BMP2A
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DescriptionA protein involved in the hedgehog and TGF beta signaling pathway
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RecombinantYes
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SourceHuman 293 cell expressed
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Endotoxin Level< 1.0 EU per 1 ug of protein
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Biological activityED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
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Results20 to 100 ng/ml
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Molecular Weight30 to 38 kDa, homodimer, glycosylated.
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Storage Temp-20°C
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Shippinggel pack
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Shelf Life12 months
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AppearanceLyophilized
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Physical form descriptionLyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
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Reconstitution InstructionsReconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
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Background InformationBMP2 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. BioVision’s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolBMP2, GDF11, GDF10, GDF2, BMP1, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2
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Short nameCellExp™ BMP-2, Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ BMP-2, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein 2
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Synonyms gene
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Locus
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Discovery year1990-06-11
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Entrez gene record
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Pubmed identfication
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Classification
- Bone morphogenetic proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 11
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-12-02
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Entrez gene record
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Pubmed identfication
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 10
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namegrowth differentiation factor 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Transforming growth factor beta superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein 1
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Synonyms gene
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Synonyms gene name
- procollagen C-endopeptidase
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Synonyms
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Synonyms name
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Locus
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Discovery year1990-06-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Bone morphogenetic proteins
- Astacins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1289-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1289 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 521-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR515 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 512-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 7-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR7 family
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data