A-1210477

  • Catalog number
    B1826-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
  • Description
    A-1210477 is a potent MCL-1 inhibitor (Ki = 0.45 nM in TR-FRET-binding assays). Acts as a weak inhibitor of BCL-2 (Ki = 0.132 μM) and BCL-XL(Ki>0.660 μM).
  • CAS Number
    1668553-26-1
  • Structure Available
    Yes
  • Molecular Formula
    C₄₆H₅₅N₇O₇S
  • Molecular Weight
    850.04
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and light
  • Tag Line
    A potent MCL-1 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel Pack
  • Shelf Life
    36 months
  • PubChem CID
    66575373
  • SMILES
    CC1=NN(C(=C1C2=CC=CC3=C2N(C(=C3CCCOC4=CC=CC5=CC=CC=C54)C(=O)O)CCN6CCOCC6)COC7=CC=C(C=C7)N8CCN(CC8)S(=O)(=O)N(C)C)C
  • InChi
    InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-50-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2,1-4H3,(H,54,55)
  • InChi Key
    XMVAWGSQPHFXKU-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    HLA-A, IGHV5-10-1, CIDEA, RPA1, CDC37P1, OR1Q1, FABP4, LINC01139, GTF2E1
  • Short name
    A-1210477
  • Alternative name
    A-1210477
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin heavy variable 5-10-1
  • Synonyms gene
  • Synonyms gene name
    • immunoglobulin heavy variable 5-A (provisional, gene/pseudogene)
    • immunoglobulin heavy variable 5-A (provisional)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-04
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin heavy locus at 14q32.33
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    general transcription factor IIE subunit 1
  • Synonyms gene name
    • general transcription factor IIE, polypeptide 1 (alpha subunit, 56kD)
    • general transcription factor IIE, polypeptide 1, alpha 56kDa
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1993-08-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • General transcription factor IIE complex subunits
  • VEGA ID
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