Leflunomide

• Catalog number
  1972-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide; HWA486,
• Description
  Cell-permeable. An immunosuppressive agent. Inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNF-dependent NF-κB activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.
• CAS Number
  75706-12-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₂H₉F₃N₂O₂
• Molecular Weight
  270.21
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (100 mM) or Ethanol (100 mM)
• Handling
  Protect from light and air
• Tag Line
  An immunosuppressant and a Tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• MDL Number
  MFCD00867593
• PubChem CID
  3899
• PubChem CID Link
• SMILES
  CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
• InChi
  InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13, 14)15/h2-6H,1H3,(H,17,18)
• InChi Key
  VHOGYURTWQBHIL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Leflunomide  
• Short name
  Leflunomide
• Alternative name
  Leflunomide

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