Factor VIII Antibody

• Catalog number
  bs-0434R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Factor VIII Primary Polyclonal Antibody
• Also known as
  Factor VIII PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Factor VIII
• Specificity
  This is a highly specific antibody against Factor VIII.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  420-470/2258
• Source
  KLH conjugated synthetic peptide derived from rat factor VIII
• Gene ID number
  302470
• Swiss Prot
  Q7TN96
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  coagulation factor VIII; Ahf; Antihemophilic factor; Coagulation factor VIII; Coagulation factor VIII procoagulent component; Coagulation factor VIIIc; Dna segment on chromosome x unique 1253 expressed sequence; Dxs1253e; F8; F8 protein;F8c; FactorVIII; FVIII; Hema coagulation factor VIIIc procoagulent component; Hemophilia a; Hemophilia classic;
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
• French translation
  anticorps

• Gene target
  Factor   VIII  
• Gene symbol
  COX8A, G3BP1, MARCHF8
• Short name
  Anti-Factor VIII
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Factor VIII Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:2294
• Gene
  COX8A
• Long gene name
  cytochrome c oxidase subunit 8A
• Synonyms gene
  • COX8
• Synonyms gene name
  • cytochrome c oxidase subunit VIII
  • cytochrome c oxidase subunit VIIIA (ubiquitous)
• Synonyms
  • COX8-2
  • COX8L
  • VIII-L
  • COX
  • VIII
• GenBank acession
  • J04823
• Locus
  11q13.1
• Discovery year
  1989-06-30
• Entrez gene record
  1351
• Pubmed identfication
  • 2543673
  • 2847943
  • 26685157
• RefSeq identity
  • NM_004074
• Classification
  • Mitochondrial complex IV: cytochrome c oxidase subunits
• VEGA ID
  OTTHUMG00000167785

Gene info

• Identity
  HGNC:30292
• Gene
  G3BP1
• Long gene name
  G3BP stress granule assembly factor 1
• Synonyms gene name
  • GTPase activating protein (SH3 domain) binding protein 1
• Synonyms
  • HDH-VIII
  • G3BP
• Synonyms name
  • Ras-GTPase-activating protein SH3-domain-binding protein
  • DNA helicase VIII
• GenBank acession
  • BC006997
• Locus
  5q33.1
• Discovery year
  2006-10-25
• Entrez gene record
  10146
• Pubmed identfication
  • 8649363
  • 9889278
  • 25229650
• RefSeq identity
  • NM_005754
• Classification
  • RNA binding motif containing
  • Endoribonucleases
• VEGA ID
  OTTHUMG00000130123

Gene info

• Identity
  HGNC:23356
• Gene
  MARCHF8
• Long gene name
  membrane associated ring-CH-type finger 8
• Synonyms gene
  • MIR
  • MARCH8
• Synonyms gene name
  • c-mir, cellular modulator of immune recognition
  • membrane-associated ring finger (C3HC4) 8
  • membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
• Synonyms
  • c-MIR
  • CMIR
  • MARCH-VIII
  • RNF178
• GenBank acession
  • AL833316
• Locus
  10q11.21-q11.22
• Discovery year
  2003-11-12
• Entrez gene record
  220972
• Pubmed identfication
  • 12582153
  • 14722266
• RefSeq identity
  • NM_145021
• Classification
  • Ring finger proteins
  • Membrane associated ring-CH-type fingers
• VEGA ID
  OTTHUMG00000019345

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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