KLRB1, human recombinant

• Catalog number
  7352-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Killer cell lectin-like receptor subfamily B member 1, CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A, NKRP1A
• Alternative_names
  Killer cell lectin-like receptor subfamily B member 1, CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKR-P1A, NKRP1A
• Description
  Plays an inhibitory role on natural killer (NK) cells cytotoxicity
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥85%
• Assay
  SDS-PAGE
• Molecular Weight
  21 kDa (183 aa, 67-225 aa + His Tag), confirmed by MALDI-TOF.
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Concentration
  1 mg/ml
• Appearance
  Liquid
• Physical form description
  1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
• Background Information
  Killer cell lectin-like receptor subfamily B member 1, also known as KLRB1, plays an inhibitory role on natural killer (NK) cells cytotoxicity. Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. Recombinant human KLRB1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Amino acid sequence
  MGSSHHHHHH SSGLVPRGSH MGSM QKSSIE KCSVDIQQSR NKTTERPGLL NCPIYWQQLR EKCLLFSHTV NPWNNSLADC STKESSLLLI RDKDELIHTQ NLIRDKAILF WIGLNFSLSE KNWKWINGSF LNSNDLEIRG DAKENSCISI SQTSVYSEYC STEIRWICQK ELTPVRNKVY PDS
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  KLRB1  
• Gene symbol
  KLRB1
• Short name
  KLRB1, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  KLRB1, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6373
• Gene
  KLRB1
• Long gene name
  killer cell lectin like receptor B1
• Synonyms gene
  • NKR
• Synonyms gene name
  • killer cell lectin-like receptor subfamily B, member 1
• Synonyms
  • CD161
  • NKR-P1
  • NKR-P1A
  • hNKR-P1A
  • CLEC5B
• Synonyms name
  • natural killer cell surface protein P1A
• GenBank acession
  • U11276
• Locus
  12p13.31
• Discovery year
  1998-01-16
• Entrez gene record
  3820
• Pubmed identfication
  • 8077657
• RefSeq identity
  • NM_002258
• Classification
  • Killer cell lectin like receptors
  • C-type lectin domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000168581

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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