Recombinant Human IGJ / Immunoglobulin J chain Protein (His tag) 200µg
-
Catalog number
PKSH030760-200µg
-
Price
Please ask
-
Size
200µg
-
-
Synonym
IGCJ;JCH
-
Activity
NA
-
Sequence
Gln 23-Asp 159
-
Fusion tag
C-His
-
Accession
NP_653247.1
-
Expressed Host
E. coli
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
＞90 % as determined by SDS-PAGE
-
Endotoxin
Please contact us for more information.
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
17 kDa
-
AP Mol Mass
26 kDa
-
Formulation
Lyophilized from sterile PBS, pH 8.0
-
Reconstitution
Please refer to it for detailed information.
-
Background
Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. Immunoglobulin J chain / IGJ also help to bind these immunoglobulins to secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but apparently also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.
-
-
-
Conjugation
histidine
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
JCHAIN
-
Short name
Recombinant IGJ / Immunoglobulin J chain Protein (His tag) 200µg
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Label
His
-
Species
Human, Humans
-
Alternative name
Rec. H. sapiens immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides / Immunoglobulin J epitope Protein (histidine detection labelled) 200µg
-
Alternative technique
rec
-
Alternative to gene target
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides, IGCJ and JCH, IGJ and IDBG-22626 and ENSG00000132465 and 3512, peptidoglycan binding, Extracellular, Igj and IDBG-177206 and ENSMUSG00000067149 and 16069, IGJ and IDBG-642895 and ENSBTAG00000018531 and 280821
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
