MMP 16 (MT3-MMP) catalytic domain (Recombinant Protein)
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Catalog number30 100 302
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PricePlease ask
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Size10 µg/ 50µl
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Protein typeRecombinant
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Protein subtypeEC 3.4.24.80
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Protein familyMatrix Metalloproteinases, matrixins
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Protein descriptionMMP16 is a endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
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Research area interestsDiseases associated with MMP16 include Osteochondrosis. Among its related pathways are Matrix Metalloproteinases and MicroRNAs in cancer.
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Package formliquid
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Tested applicationsActivation of progelatinase A; Degradation of extracellular Matrix; Screening and evaluation of MMP inhibitors; Antigen standard
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Other namesMembrane-Type 3 Matrix Metalloproteinase
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Peptide sequenceL T G R K W Q H K H I T Y S I K N V T P K V G D P E T R K A I R R A F D V W Q N V T P L T F E E V P Y S E L E N G K R D V D I T I I F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N P N H D G N D L F L V A V H E L G H A L G L E H S N D P T A I M A P F Y Q Y M E T D N F K L P N D D L Q G I Q K I Y G P P D K I P P P T R P L P T V P P H R
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Available target modificationNo
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Expression systemE.coli
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Product Subtypeprotein fragment
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Active formYes
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Taguntagged
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Contents50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 1 % glycerin, 0.1 % Triton X-100.
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Protein purity0.8
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Molecular weight23 kDa
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UniProt numberP51512
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Gene number4325
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AbbreviationMMP16 (partial)
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Full namematrix metallopeptidase 16 (partial)
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Other desciptionThe catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli.
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PurificationMentioned in the data sheet
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PubMed citationsSee the data sheet
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WarningsFor Research Use only.
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Shipping conditionsdry ice
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Storage conditionStore at -70°C
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Technical datasheetContact us to receive the datasheet
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolMMP16, MMP14, MMP24, MMP28, MMP17, MMP15, MMP25, MT3
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Short nameMMP 16 (MT3-MMP) catalytic domain (Recombinant Protein)
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHomo sapiens
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Alternative nameMMP 16 (MT3-MMP) catalytic domain (Rec. Protein)
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 16
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Synonyms gene
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Synonyms gene name
- matrix metalloproteinase 16 (membrane-inserted)
- chromosome 8 open reading frame 57
- matrix metallopeptidase 16 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 14
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Synonyms gene name
- matrix metalloproteinase 14 (membrane-inserted)
- matrix metallopeptidase 14 (membrane-inserted)
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Synonyms
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Synonyms name
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Locus
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Discovery year1994-11-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 24
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Synonyms gene name
- matrix metalloproteinase 24 (membrane-inserted)
- matrix metallopeptidase 24 (membrane-inserted)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 28
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Synonyms gene name
- matrix metalloproteinase 28
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-01-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 17
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Synonyms gene name
- matrix metalloproteinase 17 (membrane-inserted)
- matrix metallopeptidase 17 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 15
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Synonyms gene name
- matrix metalloproteinase 15 (membrane-inserted)
- matrix metallopeptidase 15 (membrane-inserted)
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-11-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namematrix metallopeptidase 25
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Synonyms gene
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Synonyms gene name
- matrix metalloproteinase 25
- matrix metallopeptidase-like 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-12-13
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- M10 matrix metallopeptidases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemetallothionein 3
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Synonyms gene name
- metallothionein 3 (growth inhibitory factor (neurotrophic))
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-10-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Metallothioneins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
