5-Aza-2'-deoxycytidine

  • Catalog number
    1754-10
  • Price
    Please ask
  • Size
    10 mg
  • Alternative_name
    4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-triazin-2(1H)-one; Decitabine
  • Description
    An epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.
  • CAS Number
    2353-33-5
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₈H₁₂N₄O₄
  • Molecular Weight
    228.08
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    An epigenetic modifier
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD00043011
  • PubChem CID
    451668
  • SMILES
    C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
  • InChi
    InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
  • InChi Key
    XAUDJQYHKZQPEU-KVQBGUIXSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    5-Aza-2'-deoxycytidine
  • Alternative name
    5-Aza-2'-deoxycytidine
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