115-7C, Hsp70 Activator

  • Catalog number
    SIH-123-5MG
  • Price
    Please ask
  • Size
    5 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    No Available. See included datasheet
  • Description
    Hsp70 Activator
  • Molecular weight
    477,34 g/mol
  • Primary research fields
    Cancer, Heat Shock
  • Other name
    4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2
  • Product category
    Small Molecules
  • Product type
    Activator
  • Chemical formula
    C23H22Cl2N2O5
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble in DMSO (20 mg/ml)
  • Physical appearance
    White solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
  • PubChem number
    Refer to PubChem
  • Scientific context
    115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
  • Bibliography
    1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486
  • Release date
    30-Aug-2016
  • PubMed number
    27611863
  • Tested applications
    In vitro activation
  • Tested reactivity
    Cercariae
  • Representative figure legend
    Chemical structure of 115-7C (SIH-123), a Hsp70 Activator. Molecular Formula: C₂₃H₂₂Cl₂N₂O₅. Molecular Weight: 477.34 g/mol. Chemical structure of 115-7C, a Hsp70 Activator (SIH-123). Molecular Formula: C₂₃H₂₂Cl₂N₂O₅.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.005
  • Gene target
  • Gene symbol
    SNORA47, SNORD23, MIRLET7C, RRP15, MAP7, LIN7C, CLIP2, OR4H6P
  • Short name
    115-7C, Hsp70 Activator
  • Alternative name
    115-7C, Hsp70 Activator
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
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