115-7C, Hsp70 Activator
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Catalog numberSIH-123-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS numberNo Available. See included datasheet
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DescriptionHsp70 Activator
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Molecular weight477,34 g/mol
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Primary research fieldsCancer, Heat Shock
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Other name4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2
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Product categorySmall Molecules
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Product typeActivator
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Chemical formulaC23H22Cl2N2O5
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OriginSynthetic
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Purity pourcentage>98%
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Soluble inSoluble in DMSO (20 mg/ml)
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem numberRefer to PubChem
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Scientific context115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
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Bibliography1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486
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Release date30-Aug-2016
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PubMed number27611863
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Tested applicationsIn vitro activation
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Tested reactivityCercariae
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Representative figure legendChemical structure of 115-7C (SIH-123), a Hsp70 Activator. Molecular Formula: C₂₃H₂₂Cl₂N₂O₅. Molecular Weight: 477.34 g/mol. Chemical structure of 115-7C, a Hsp70 Activator (SIH-123). Molecular Formula: C₂₃H₂₂Cl₂N₂O₅.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Gene target
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Gene symbolSNORA47, SNORD23, MIRLET7C, RRP15, MAP7, LIN7C, CLIP2, OR4H6P
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Short name115-7C, Hsp70 Activator
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Alternative name115-7C, Hsp70 Activator
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Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, H/ACA box 47
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Synonyms
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Locus
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Discovery year2006-04-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, H/ACA box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 23
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-05-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namemicroRNA let-7c
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIRLET7 family
Gene info
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Identity
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Gene
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Long gene nameribosomal RNA processing 15 homolog
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Synonyms gene
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Synonyms gene name
- KIAA0507
- ribosomal RNA processing 15 homolog (S. cerevisiae)
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Synonyms
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Locus
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Discovery year2007-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ribosomal biogenesis factors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicrotubule associated protein 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-01-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelin-7 homolog C, crumbs cell polarity complex component
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Synonyms gene name
- lin-7 homolog C (C. elegans)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-09-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PDZ domain containing
- Crumbs complex
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCAP-Gly domain containing linker protein 2
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Synonyms gene
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Synonyms gene name
- cytoplasmic linker 2
- Williams-Beuren syndrome chromosome region 3
- CAP-GLY domain containing linker protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-09-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 4 subfamily H member 6 pseudogene
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 4, subfamily H, member 8 pseudogene
- olfactory receptor, family 4, subfamily H, member 6 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-11-25
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Entrez gene record
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Pubmed identfication
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Classification
- Olfactory receptors, family 4
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VEGA ID