LY-2874455

  • Catalog number
    9532-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
  • Description
    LY-2874455 is a potent, FGF/FGFR inhibitor. Exhibits potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. It displays a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.
  • CAS Number
    1254473-64-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₁H₁₉Cl₂N₅O₂
  • Molecular Weight
    444.31
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>4 mg/ml)
  • Handling
    Protect from air and light
  • Tag Line
    A potent, FGF/FGFR inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • PubChem CID
    46944259
  • SMILES
    CC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO
  • InChi
    InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
  • InChi Key
    GKJCVYLDJWTWQU-CXLRFSCWSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    ARHGDIB
  • Short name
    LY-2874455
  • Alternative name
    LY-2874455
Gene info
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