LY-2874455
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Catalog number9532-25
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PricePlease ask
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Size25 mg
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Alternative_name(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol
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DescriptionLY-2874455 is a potent, FGF/FGFR inhibitor. Exhibits potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. It displays a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.
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CAS Number1254473-64-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₁H₁₉Cl₂N₅O₂
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Molecular Weight444.31
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>4 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent, FGF/FGFR inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID46944259
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SMILESCC(C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3C=CC4=CN(N=C4)CCO
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InChiInChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
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InChi KeyGKJCVYLDJWTWQU-CXLRFSCWSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolARHGDIB
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Short nameLY-2874455
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Alternative nameLY-2874455
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Gene info
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Identity
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Gene
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Long gene nameRho GDP dissociation inhibitor beta
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Synonyms gene
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Synonyms gene name
- Rho GDP dissociation inhibitor (GDI) beta
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Synonyms
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GenBank acession
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Locus
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Discovery year1994-08-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor ligands
- Minor histocompatibility antigens
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VEGA ID