Rat IGF-II

Type

IGF-II Family
Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.
About

Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
Latin name

Rattus norvegicus

Identity

HGNC:3535
Gene

F2
Long gene name

coagulation factor II, thrombin
Synonyms gene name
- coagulation factor II (thrombin)
Synonyms name
- prepro-coagulation factor II
GenBank acession
- M33031
Locus

11p11.2
Discovery year

2001-06-22
Entrez gene record

2147
Classification
- Receptor ligands
- Gla domain containing
- Complement system regulators and receptors
VEGA ID

OTTHUMG00000150344
Locus Specific Databases
- LRG_551