SMN1 Polyclonal Antibody

• Catalog number
  CAC07911
• Price
  Please ask
• Size
  100 μg

• Other name
  Survival motor neuron protein,Component of gems 1,Gemin-1,SMN1,SMN,SMNT,SMN2,SMNC
• Immunogen
  Recombinant Human Survival motor neuron protein (3-194AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB,IHC,IF. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200,IF:1:50-1:200
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  Q16637
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Protein G purified, >95%
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  SMN1  
• Gene symbol
  SMN1
• Short name
  SMN1 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  SMN1 polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:11117
• Gene
  SMN1
• Long gene name
  survival of motor neuron 1, telomeric
• Synonyms gene
  • SMA@
  • SMA
• Synonyms gene name
  • spinal muscular atrophy (Werdnig-Hoffmann disease, Kugelberg-Welander disease)
• Synonyms
  • BCD541
  • SMNT
  • SMA1
  • SMA2
  • SMA3
  • GEMIN1
  • TDRD16A
• Synonyms name
  • gemin-1
  • tudor domain containing 16A
• GenBank acession
  • U18423
• Locus
  5q13.2
• Discovery year
  1996-12-12
• Entrez gene record
  6606
• Pubmed identfication
  • 7813012
• RefSeq identity
  • NM_000344
• Classification
  • SMN complex
  • Tudor domain containing
• VEGA ID
  OTTHUMG00000099361
• Locus Specific Databases
  • SMN1 - Spinal Muscular Atrophy (SMA)
  • Leiden Muscular Dystrophy pages
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_676

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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