5-Fluoroorotic Acid Monohydrate-13C15N2
-
Catalog number
F595002
-
Price
Please ask
-
Size
1 mg
-
-
Chemical available in other sizes
Please inquire size and price
-
Stock availability
Please Inquire
-
Cas number
This product doesn't have CAS Number
-
Chemical s molecular weight
195.08
-
Chemical s main applications
5-Fluoroorotic Acid Monohydrate-13C15N2 is the isotope analog of 5-Fluoroorotic Acid Monohydrate, (5-FOA). 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
-
Chemical s category
Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, 5-FOA
-
Other name
5-FOA-13C15N2
-
Chemical s formula
C413CH5F15N2O5
-
Physical properties
No Data Available
-
Melting temperature
No Data Available
-
Boiling temperature
No Data Available
-
Chemical s soluble in
No Data Available
-
Stability conditions
No Data Available
-
Storage
No Data Available
-
Product images
Similar products