Fibrinogen (plasminogen depleted), Human Plasma

  • Catalog number
    7692-1
  • Price
    Please ask
  • Size
    1 g
  • Synonyms
    Factor 1
  • Alternative_names
    Factor 1
  • Description
    A part of the coagulation cascade of proteins.
  • Recombinant
    No
  • Source
    Human Plasma
  • Purity by SDS PAGE
    ≥95%
  • Assay
    SDS-PAGE
  • Biological activity
    > 95% clottable by functional assays
  • Results
    > 95% clottable by functional assays
  • Molecular Weight
    330.00 kDa
  • Storage Temp
    -80°C
  • Shipping
    Dry Ice
  • Shelf Life
    12 months
  • Appearance
    Liquid
  • Physical form description
    In 20 mM Sodium Citrate-HCl pH 7.4.
  • Background Information
    Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
  • Short name
    Fibrinogen (plasminogen depleted), Plasma
  • Species
    Human, Humans
  • Alternative name
    Fibrinogen (plasminogen depleted), H. sapiens Plasma
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