A83 01, ALK kinase inhibitor
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Catalog numberSIH-423-5MG
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PricePlease ask
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Size5 mg
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Stock availabilitIn StockIn Stock
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CAS number909910-43-6
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DescriptionALK kinase inhibitor
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Molecular weight421.5 g/mol
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Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide, A-83-01, A83-01
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC25H19N5S
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OriginSynthetic
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Purity pourcentage≥98% (HPLC)
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Soluble inSoluble to 50 mM in DMSO
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Physical appearanceWhite to beige powder
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity-single exposure (Category 3), Respiratory system Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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PubChem number16218924
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Scientific contextA83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.
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Bibliography1. Li W., et al. (2009) Stem Cell 4(1): 16–19. 2. Cherukuri P., et al. (2012). PloS One. 7(11): e50066.
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Release date1-Oct-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of A83 01 (SIH-423), a ALK kinase inhibitor. CAS #: 909910-43-6. Molecular Formula: C25H19N5S. Molecular Weight: 421.5 g/mol. Chemical structure of A83 01, a ALK kinase inhibitor (SIH-423). CAS # 909910-43-6. Molecular Formula: C25H19N5S.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.005
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolALK, ENPP7, TGFBR1, BMPR2
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Short nameA83 01, ALK kinase inhibitor
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Alternative nameA83 01, anaplastic lymphoma receptor tyrosine kinase phosphorylation catalyst suppressor
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Alternative to gene targetanaplastic lymphoma receptor tyrosine kinase, CD246 and NBLST3, ALK and IDBG-42084 and ENSG00000171094 and 238, transferase activity, Plasma membranes, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642
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Gene info
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Identity
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Gene
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Long gene nameALK receptor tyrosine kinase
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Synonyms gene name
- anaplastic lymphoma kinase (Ki-1)
- anaplastic lymphoma receptor tyrosine kinase
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-08-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Receptor tyrosine kinases
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameectonucleotide pyrophosphatase/phosphodiesterase 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-04-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ectonucleotide pyrophosphatase/phosphodiesterase family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametransforming growth factor beta receptor 1
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Synonyms gene
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Synonyms gene name
- multiple self-healing squamous epithelioma
- transforming growth factor beta receptor I
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-09-30
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Entrez gene record
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Pubmed identfication
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Classification
- Type 1 receptor serine/threonine kinases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namebone morphogenetic protein receptor type 2
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Synonyms gene
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Synonyms gene name
- primary pulmonary hypertension 1
- bone morphogenetic protein receptor, type II (serine/threonine kinase)
- bone morphogenetic protein receptor type II
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-03-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Type 2 receptor serine/threonine kinases
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VEGA ID
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Locus Specific Databases
