Caspase-8, active, pro (CASP8, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like Protease, FADD-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-associated ced-3 Homolog, MACH, MCH5)

• Catalog number
  MBS642399
• Price
  Please ask
• Size
  5x0.05 mL

• Products_type
  Antibody
• Products_short_name
  [Caspase-8, active, pro]
• Products_name_syn
  [Anti -Caspase-8, active, pro (CASP8, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like Protease, FADD-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-associated ced-3 Homolog, MACH, MCH5)]
• Other_names
  [Caspase-8; Caspase-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease; caspase 8, apoptosis-related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog]
• Other_gene_names
  [CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; MCH5; CASP-8; FLICE; MACH]
• Clonality
  Polyclonal
• Reactivity
  Human, Mouse, Rat
• Specificity
  Recognizes human caspase-8 forms that contain the peptide immunogen sequence (PQPTFTLRKKLVFPSD). Species Crossreactivity: gerbil, mouse, rat.
• Purity
  Serum Serum
• Form
  Supplied as a liquid, 0.05% sodium azide.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Gene
  Cys or cysteines ChEMBL54943

• Gene target
  Caspase-8   active   pro   CASP8   Apoptotic   Cysteine   Protease   Apoptotic   Protease   Mch-5   CAP4   FADD-homologous   ICE/ced-3-like   Protease   FADD-like   ICE   FLICE   ICE-like   Apoptotic   Protease   MORT1-associated   ced-3   Homolog   MACH   MCH5  
• Gene symbol
  FADD, CASP1, CASP9, CASP5, CASP8, CES2, CARD18, CARD16, CASP4, CASP7
• Short name
  Caspase-8, active, pro (CASP8, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like Protease, FADD-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-associated ced-3 Homolog, MACH, MCH5)
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  caspase-8, functionnal, L-proline (caspase 8, apoptosis-related cysteine peptidase, Apoptotic Cysteine Protease, Apoptotic Protease Mch-5, CAP4, Fas (tumor necrosis factor receptor superfamily, member 6) (TNFRSF6)-associated via death domain-homologous ICE/ced-3-like Protease, Fas (tumor necrosis factor receptor superfamily, member 6) (TNFRSF6)-associated via death domain-like ICE, FLICE, ICE-like Apoptotic Protease 5, MORT1-associated ced-3 Homolog, MACH, MCH5)
• Alternative to gene target
  Fas (TNFRSF6)-associated via death domain, MORT1, FADD and IDBG-62144 and ENSG00000168040 and 8772, identical protein binding, Plasma membranes, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720

Gene info

• Identity
  HGNC:3573
• Gene
  FADD
• Long gene name
  Fas associated via death domain
• Synonyms gene name
  • Fas (TNFRSF6)-associated via death domain
• Synonyms
  • MORT1
  • GIG3
• Synonyms name
  • Fas-associating protein with death domain
  • Fas-associating death domain-containing protein
  • mediator of receptor-induced toxicity
  • growth-inhibiting gene 3 protein
• GenBank acession
  • U24231
• Locus
  11q13.3
• Discovery year
  1999-05-07
• Entrez gene record
  8772
• Pubmed identfication
  • 7536190
  • 7538907
• RefSeq identity
  • NM_003824
• Classification
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000167264
• Locus Specific Databases
  • LRG_228

Gene info

• Identity
  HGNC:1499
• Gene
  CASP1
• Long gene name
  caspase 1
• Synonyms gene
  • IL1BC
• Synonyms gene name
  • caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • caspase 1, apoptosis-related cysteine peptidase
• Synonyms
  • ICE
• Synonyms name
  • caspase-1
  • interleukin 1, beta, convertase
• GenBank acession
  • U13697
• Locus
  11q22.3
• Discovery year
  1992-05-07
• Entrez gene record
  834
• Pubmed identfication
  • 1373520
  • 9250871
• RefSeq identity
  • NM_033292
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000048072

Gene info

• Identity
  HGNC:1511
• Gene
  CASP9
• Long gene name
  caspase 9
• Synonyms gene name
  • caspase 9, apoptosis-related cysteine protease
  • caspase 9, apoptosis-related cysteine peptidase
• Synonyms
  • MCH6
  • ICE-LAP6
  • APAF-3
  • PPP1R56
• Synonyms name
  • protein phosphatase 1, regulatory subunit 56
• GenBank acession
  • U60521
• Locus
  1p36.21
• Discovery year
  1996-11-11
• Entrez gene record
  842
• Pubmed identfication
  • 8663294
  • 9390557
• RefSeq identity
  • NM_032996
• Classification
  • Caspases
  • Apoptosome
  • Caspase recruitment domain containing
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000002256

Gene info

• Identity
  HGNC:1506
• Gene
  CASP5
• Long gene name
  caspase 5
• Synonyms gene name
  • caspase 5, apoptosis-related cysteine protease
  • caspase 5, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)III
• Locus
  11q22.3
• Discovery year
  1996-09-13
• Entrez gene record
  838
• Pubmed identfication
  • 7797592
  • 9250871
• RefSeq identity
  • NM_004347
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000048073

Gene info

• Identity
  HGNC:1509
• Gene
  CASP8
• Long gene name
  caspase 8
• Synonyms gene name
  • caspase 8, apoptosis-related cysteine protease
  • caspase 8, apoptosis-related cysteine peptidase
• Synonyms
  • MCH5
  • MACH
  • FLICE
  • Casp-8
• GenBank acession
  • U60520
• Locus
  2q33.1
• Discovery year
  1996-11-11
• Entrez gene record
  841
• Pubmed identfication
  • 8681376
  • 8681377
• RefSeq identity
  • NM_001228
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000132821
• Locus Specific Databases
  • CASP8base: Mutation registry for Caspase 8 deficiency
  • LRG_34

Gene info

• Identity
  HGNC:1864
• Gene
  CES2
• Long gene name
  carboxylesterase 2
• Synonyms gene name
  • carboxylesterase 2 (intestine, liver)
• Synonyms
  • CE-2
  • iCE
  • CES2A1
• GenBank acession
  • BC032095
• Locus
  16q22.1
• Discovery year
  1993-09-30
• Entrez gene record
  8824
• Pubmed identfication
  • 9169443
  • 9144407
  • 20931200
• RefSeq identity
  • NM_003869
• Classification
  • Carboxylesterases
• VEGA ID
  OTTHUMG00000137517

Gene info

• Identity
  HGNC:28861
• Gene
  CARD18
• Long gene name
  caspase recruitment domain family member 18
• Synonyms gene name
  • caspase recruitment domain family, member 18
• Synonyms
  • UNQ5804
  • ICEBERG
  • pseudo-ICE
• GenBank acession
  • AY358231
• Locus
  11q22.3
• Discovery year
  2008-09-02
• Entrez gene record
  59082
• Pubmed identfication
  • 11051551
• RefSeq identity
  • NM_021571
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166165

Gene info

• Identity
  HGNC:33701
• Gene
  CARD16
• Long gene name
  caspase recruitment domain family member 16
• Synonyms gene name
  • caspase recruitment domain family, member 16
• Synonyms
  • COP1
  • COP
  • PSEUDO-ICE
  • LLID-114769
• Locus
  11q22.3
• Discovery year
  2008-09-15
• Entrez gene record
  114769
• Pubmed identfication
  • 11432859
  • 11536016
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166157

Gene info

• Identity
  HGNC:1505
• Gene
  CASP4
• Long gene name
  caspase 4
• Synonyms gene name
  • caspase 4, apoptosis-related cysteine protease
  • caspase 4, apoptosis-related cysteine peptidase
• Synonyms
  • ICE(rel)II
  • ICH-2
  • TX
• GenBank acession
  • U25804
• Locus
  11q22.3
• Discovery year
  1996-07-22
• Entrez gene record
  837
• Pubmed identfication
  • 7797510
  • 9250871
• RefSeq identity
  • NM_001225
• Classification
  • Caspases
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000166078

Gene info

• Identity
  HGNC:1508
• Gene
  CASP7
• Long gene name
  caspase 7
• Synonyms gene name
  • caspase 7, apoptosis-related cysteine protease
  • caspase 7, apoptosis-related cysteine peptidase
• Synonyms
  • MCH3
  • CMH-1
  • ICE-LAP3
• GenBank acession
  • U37448
• Locus
  10q25.3
• Discovery year
  1996-07-22
• Entrez gene record
  840
• Pubmed identfication
  • 8521391
  • 8576161
• RefSeq identity
  • NM_033338
• Classification
  • Caspases
• VEGA ID
  OTTHUMG00000019076

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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