Anti-Connexin 43 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-0651R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  Connexin 43
• Specificity
  This antibody reacts specifically with Connexin 43
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Cytoplasm
• Antigen Source
  KLH conjugated synthetic peptide derived from human Connexin-43
• Gene ID
  2697
• Swiss Prot
  P17302
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Dog
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; Gap junction alpha-1 protein; Connexin-43; Gap junction 43 kDa heart protein; GJA1
• Also known as
  Connexin 43 Polyclonal Antibody
• Other name
  Anti-Connexin 43 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  Connexin  
• Gene symbol
  GJA1P1, GJA1
• Short name
  Anti-Connexin 43
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  Connexin 43 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:4275
• Gene
  GJA1P1
• Long gene name
  gap junction protein alpha 1 pseudogene 1
• Synonyms gene name
  • gap junction protein, alpha 1, 43kD (connexin 43) pseudogene 1
  • gap junction protein, alpha 1, 43kDa (connexin 43) pseudogene 1
  • gap junction protein, alpha 1, 43kDa pseudogene 1
• GenBank acession
  • M65189
• Locus
  5q21.3
• Discovery year
  1991-01-30
• Entrez gene record
  2698
• Pubmed identfication
  • 1646158
  • 11741837
• RefSeq identity
  • NG_003029
• VEGA ID
  OTTHUMG00000162850

Gene info

• Identity
  HGNC:4274
• Gene
  GJA1
• Long gene name
  gap junction protein alpha 1
• Synonyms gene
  • ODDD
  • GJAL
• Synonyms gene name
  • gap junction protein, alpha-like
  • gap junction protein, alpha 1, 43kDa (connexin 43)
  • gap junction protein, alpha 1, 43kDa
• Synonyms
  • CX43
  • ODD
  • ODOD
  • SDTY3
• Synonyms name
  • oculodentodigital dysplasia (syndactyly type III)
  • connexin 43
• GenBank acession
  • BC026329
• Locus
  6q22.31
• Discovery year
  1990-08-03
• Entrez gene record
  2697
• Pubmed identfication
  • 10331943
  • 1646158
• RefSeq identity
  • NM_000165
• Classification
  • Gap junction proteins
• VEGA ID
  OTTHUMG00000015479
• Locus Specific Databases
  • Hereditary Hearing Loss Homepage
  • LRG_1289

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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