MyD88 Antibody
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Catalog number3244R-100
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PricePlease ask
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Size100 µg
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Antibody TargetMYD88
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Target Alternative NameMyeloid differentiation primary response protein, MyD88
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Antibody TypePolyclonal
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Species ReactivitiesHuman, mouse, rat, monkey
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Immunogen SequenceSynthetic peptide surrounding amino acid 283 of rat MyD88
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AccessionQ6Y1S1
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Gene Id301059
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AppearanceColorless liquid
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FormLiquid
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Concentration0.5 mg/ml
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Formulation100 µg (0.5 mg/ml) affinity purified rabbit anti- MyD88 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal
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PurificationAffinity purified
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ApplicationWestern blot
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Positive ControlRat kidney tissue lysate
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Application And UsagesWestern Blot analysis (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide (Cat.# 3244RBP-50) is available separately.
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DescriptionMyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment. Dominant-negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 is a general adaptor protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolMYD88, TIRAP, MAL
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Short nameMyD88 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative namemyeloid differentiation primary response 88 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetmyeloid differentiation primary response 88, MYD88D, MYD88 and IDBG-25713 and ENSG00000172936 and 4615, TIR domain binding, Plasma membranes, Myd88 and IDBG-204565 and ENSMUSG00000032508 and 17874, MYD88 and IDBG-644299 and ENSBTAG00000000563 and 444881
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Gene info
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Identity
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Gene
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Long gene nameMYD88 innate immune signal transduction adaptor
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Synonyms gene name
- myeloid differentiation primary response gene (88)
- myeloid differentiation primary response 88
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GenBank acession
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Locus
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Discovery year1997-12-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- TIR domain containing
- My-T-BRC complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameTIR domain containing adaptor protein
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Synonyms gene name
- Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-06-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- TIR domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemal, T cell differentiation protein
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Synonyms gene name
- mal, T-cell differentiation protein
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Synonyms
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Synonyms name
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MARVEL domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data