GHR, GHBP, GH receptor, Somatotropin receptor
GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein
A carrier protein for growth hormone
Purity by SDS-PAGE
GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
30.3 kDa (19-256 aa + N-terminal poly-his tag)
Physical form description
GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO₃.
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
Centrifuge the vial prior to opening.
For Research Use Only! Not to be used in humans
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
GHBP, H. sapiens recombinant