GHBP, human recombinant

• Catalog number
  4972-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  GHR, GHBP, GH receptor, Somatotropin receptor
• Alternative_names
  GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein
• Description
  A carrier protein for growth hormone
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.
• Molecular Weight
  30.3 kDa (19-256 aa + N-terminal poly-his tag)
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO₃.
• Reconstitution Instructions
  Reconstitute in sterile dH₂O not less than 100 ug/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  GHBP  
• Gene symbol
  GHR
• Short name
  GHBP, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  GHBP, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:4263
• Gene
  GHR
• Long gene name
  growth hormone receptor
• Synonyms
  • GHBP
• Synonyms name
  • growth hormone binding protein
• Locus
  5p13.1-p12
• Discovery year
  1989-06-30
• Entrez gene record
  2690
• RefSeq identity
  • NM_000163
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000094791
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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