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Alternative_name
4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic ac
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Description
RQ-00203078 is a potent, selective TRPM8 antagonist (IC₅₀ values are 5.3 and 8.3 nM for rat and human channels respectively). Displays >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. RQ-00203078 blocks TRPM8 activity and reduces the invasion potential of oral squamous carcinoma cell lines. RQ-00203078 (RQ) profoundly reduced such agonist-induced cation currents.
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CAS Number
1254205-52-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₁H₁₃ClF₆N₂O₅S
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Molecular Weight
554.85
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>40 mg/ml) or EtOH (>40 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent, selective TRPM8 antagonist
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
49783953
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SMILES
C1=CC(=CC=C1CN(C2=C(C=C(C=N2)C(F)(F)F)Cl)S(=O)(=O)C3=CC=C(C=C3)C(=O)O)OC(F)(F)F
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InChi
InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)
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InChi Key
IJGQFZYYEHCCIZ-UHFFFAOYSA-N
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MSDS Available
Yes
