K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC₅₀ = 1.3 µM) and an antitumor agent. Induces cell death in cancer cells, blocks centrosome separation, activates the spindle checkpoint, and induces mitotic arrest in cells accompanied by the formation of monopolar spindles.
White to off-white solid
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
DMSO (>20 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
K858 for activation
K858 to measure cellular activation
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