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Gene info
TGFBR1, an Activin/TGFb type protein kinase, is a member of the transforming growth factor-beta (TGFb) signal transduction pathway which controls multiple intracellular functions and the development and homeostasis of most organs and tissues. TGFBR1 is recruited into a heteromeric complex and is phosphorylated by ligand-bound transforming growth factor beta receptor type 2 (TGFBR2). Activated TGFBR1 phosphorylates the receptor-regulated signaling proteins Smad2 and Smad3 which translocate to the nucleus to activate transcription. Mutations in, or loss of expression of, TGFBR1 have been identified in a large number of different tumors and in Loeys-Dietz syndrome.
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Gene names
TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, Activin receptor-like kinase 5, LDS1A, LDS2A, MSSE, SKR4, TGF beta receptor I, TGF-beta receptor type-1, TGF-beta type I receptor, TbetaR-I, TGFR-1, TGF-beta receptor type I
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Antibodie s label
unlabelled serum
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Ab raised in
Rabbit
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Type
Polyclonal
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Antigen
TGFBR1 antibody was made against amino acids 158 - 179 of TGFBR1 (Human).
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Immuno application
Western Blot, immuno-histo-chemistry
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Antibody advice
TGFBR1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:2000, and immunohistochemistry starting at 1:200.
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Suspention pH azide
PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
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Keep at
Store TGFBR1 antibody at 2-8 grades C for up to 1 year. Avoid repeated freeze-thaw cycles.
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Works with
Human, Mouse, Rat
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Omim nr
547777
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Ncbi nr
P36897
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Vial with antibody
in solution
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NCBI GENE nr
7046
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GENE symbol
TGFBR1
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Antigene name
transforming growth factor, beta receptor 1
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Source
Homo sapiens
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Protein nr
P36897
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
TGFBR1
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Short name
anti-TGFBR1 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody totransforming growth factor, b receptor 1 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
transforming growth factor, beta receptor 1, AAT5 and ACVRLK4 and ALK-5 and ALK5 and ESS1 and LDS1 and LDS1A and LDS2A and MSSE and SKR4 and TGFR-1, TGFBR1 and IDBG-78488 and ENSG00000106799 and 7046, transforming growth factor beta receptor activity, Cell surfaces, Tgfbr1 and IDBG-146050 and ENSMUSG00000007613 and 21812, TGFBR1 and IDBG-634152 and ENSBTAG00000018035 and 282382
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