mTOR Inhibitor, WYE-132

• Catalog number
  2256-500
• Price
  Please ask
• Size
  500 ug

• Alternative_name
  1-{4-[1-(1,4-Dioxa-spiro[4.5]dec-8-yl)-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-methyl-urea; WYE-125132
• Description
  Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.19 nM). Displays >5000-fold selectivity over PI3Ks. WYE-132 inhibits mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo.
• CAS Number
  1144068-46-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₃N₇O
• Molecular Weight
  519.6
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (50 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A sub-nanomolar potent mTOR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD16038851
• PubChem CID
  25260757
• PubChem CID Link
• SMILES
  CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
• InChi
  InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
• InChi Key
  QLHHRYZMBGPBJG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  mTOR   Inhibitor   WYE-132  
• Gene symbol
  MRPS16, MIR132, TRERF1
• Short name
  mTOR Inhibitor, WYE-132
• Alternative name
  Mammalian target on rapamycin suppressor, WYE-132
• Alternative to gene target
  mechanistic target of rapamycin (serine/threonine kinase), FRAP and FRAP1 and FRAP2 and RAFT1 and RAPT1, MTOR and IDBG-89258 and ENSG00000198793 and 2475, transferase activity, nuclei, Mtor and IDBG-204403 and ENSMUSG00000028991 and 56717, MTOR and IDBG-632731 and ENSBTAG00000015325 and 100139219

Gene info

• Identity
  HGNC:14048
• Gene
  MRPS16
• Long gene name
  mitochondrial ribosomal protein S16
• Synonyms
  • CGI-132
• GenBank acession
  • AB051351
• Locus
  10q22.2
• Discovery year
  2001-02-28
• Entrez gene record
  51021
• Pubmed identfication
  • 10810093
• Classification
  • Mitochondrial ribosomal proteins
  • Small subunit mitochondrial ribosomal proteins
• VEGA ID
  OTTHUMG00000018454

Gene info

• Identity
  HGNC:31516
• Gene
  MIR132
• Long gene name
  microRNA 132
• Synonyms gene
  • MIRN132
• Synonyms
  • hsa-mir-132
• Locus
  17p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  406921
• RefSeq identity
  • NR_029674
• Classification
  • MicroRNA MIR132/212 family

Gene info

• Identity
  HGNC:18273
• Gene
  TRERF1
• Long gene name
  transcriptional regulating factor 1
• Synonyms gene
  • BCAR2
• Synonyms gene name
  • breast cancer anti-estrogen resistance 2
• Synonyms
  • TReP-132
  • HSA277276
  • RAPA
  • dJ139D8.5
• GenBank acession
  • AF297872
• Locus
  6p21.1
• Discovery year
  2003-11-26
• Entrez gene record
  55809
• Pubmed identfication
  • 11349124
• RefSeq identity
  • NM_033502
• Classification
  • Myb/SANT domain containing
• VEGA ID
  OTTHUMG00000014698

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