Monoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)
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Catalog numberK797-100
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PricePlease ask
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Size100 assays
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DescriptionOnly kit on the market to screen monoamine oxidase B (MAO-B) inhibitors
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Summary• Detection method: Fluorescence (Ex/Em = 535/587 nm) • Application: Screening/studying/characterizing MAO-B inhibitors
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Detection MethodFluorescence (Ex/Em = 535/587 nm)
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ApplicationsScreening/studying/characterizing MAO-B inhibitors
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Features Benefits• Rapid & sensitive • High-throughput assay to screen/study/characterize potential inhibitors of monoamine oxidase B • Includes Inhibitor Control [Selegiline]
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Storage Conditions-20°C
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Shipping Conditionsgel pack
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Shelf life12 months
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BackgroundMonoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity, and tissue localization. MAO-B can oxidize primary amines, but its list of specific substrates (i.e. benzylamine, phenylethylamine) is more limited compared to MAO-A. MAO-B is a mitochondrial-bound enzyme that is ubiquitously expressed throughout the brain and other tissues. It has been investigated in numerous studies including Parkinson’s disease, Alzheimer’s, and tobacco addiction. Specific MAO-B inhibitors such as selegiline, & rasagiline have been used to treat Parkinson’s patients, but their benefits are considered rather modest. BioVision’s MAO-B Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-B inhibitors. The assay is based on the fluorometric detection of H2O2, one of the byproducts generated during the oxidative deamination of MAO substrate.
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolMAOB, SNRPB, ORM2, ERAL1, OR1B1, SPIB, EXPH5, HLA-B, RELB, RPS6KA4
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Short nameMonoamine Oxidase B (MAO-B) Inhibitor Screening Kit (Fluorometric)
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Alternative nameMonoamine Oxidase B (MAO-B) suppressor detection reagent (fluorescence)
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Alternative techniquekits
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Alternative to gene targetv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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Gene info
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Identity
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Gene
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Long gene namemonoamine oxidase B
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesmall nuclear ribonucleoprotein polypeptides B and B1
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Synonyms gene
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Synonyms
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Locus
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Discovery year1988-11-28
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Entrez gene record
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Pubmed identfication
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Classification
- Small nucleolar RNA protein coding host genes
- Sm spliceosomal proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameorosomucoid 2
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Synonyms
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Synonyms name
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Locus
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Discovery year1991-03-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Lipocalins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameEra like 12S mitochondrial rRNA chaperone 1
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Synonyms gene name
- Era (E. coli G-protein homolog)-like 1
- Era G-protein-like 1 (E. coli)
- Era-like 12S mitochondrial rRNA chaperone 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-11-19
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 1 subfamily B member 1
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Synonyms gene name
- olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene)
- olfactory receptor family 1 subfamily B member 1 (gene/pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-12-09
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Entrez gene record
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RefSeq identity
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Classification
- Olfactory receptors, family 1
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSpi-B transcription factor
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Synonyms gene name
- Spi-B transcription factor (Spi-1/PU.1 related)
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Synonyms
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Locus
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Discovery year1994-12-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ETS transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameexophilin 5
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Synonyms
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Synonyms name
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Locus
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Discovery year2005-10-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, B
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Synonyms gene
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Synonyms gene name
- ankylosing spondylitis
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRELB proto-oncogene, NF-kB subunit
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Synonyms gene name
- v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-10-02
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Entrez gene record
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Pubmed identfication
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Classification
- IPT domain containing
- NF-kappa B complex subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameribosomal protein S6 kinase A4
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Synonyms gene name
- ribosomal protein S6 kinase, 90kD, polypeptide 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-03-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- AGC family kinases
- MicroRNA protein coding host genes
- MAPK activated protein kinases
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VEGA ID
