FTY720 Hydrochloride, S1P receptor ligand
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Catalog number
SIH-523-5MG
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Price
Please ask
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Size
5 mg
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Stock availabilitIn Stock
In Stock
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CAS number
162359-56-0
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Description
S1P receptor ligand
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Molecular weight
343,9 g/mol
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Primary research fields
Cell signaling
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Other name
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol,hydrochloride; Fingolimod
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Product category
Small Molecules
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Product type
Agonist
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Chemical formula
C19H34ClNO2
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)
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Physical appearance
White solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: D2B Toxic Material Causing Other Toxic Effects Moderate skin irritant Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. H412 Harmful to aquatic life with long lasting effects. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273 Avoid release to the environment. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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PubChem number
107969
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Scientific context
FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug.
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Bibliography
1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60. 2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of FTY720 Hydrochloride (SIH-523), a Sphingosine 1-phosphate receptor agonist. CAS #: 162359-56-0. Molecular Formula: C19H34ClNO2. Molecular Weight: 343.9 g/mol. Chemical structure of FTY720 Hydrochloride, a Sphingosine 1-phosphate receptor agonist (SIH-523). CAS # 162359-56-0. Molecular Formula: C19H34ClNO2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbol
MBTPS1
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Short name
FTY720 Hydrochloride, S1P receptor ligand
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Alternative name
FTY720 Hydrochloride, S1P receptor ligand
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Gene info
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