2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; OSU03012; AR-12
A novel celecoxib derivative, that acts as a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1). It displays anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase(PI3K)/Akt pathway. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.
Is it cell-permeable?
≥98% by HPLC
Is this a salt?
Protect from air and light
Maximum time for storage
White to off-white solid
DMSO (>10 mg/ml)
For cells, cell lines and tissues in culture till half confluency.
OSU-03012 for activation
OSU-03012 to measure cellular activation