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OSU 03012 for cell activation

OSU 03012 for cell activation is available 0 time from Biovision labs

Other name 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide; OSU03012; AR-12
Supplied with N/A
Description A novel celecoxib derivative, that acts as a potent inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1) activity (IC₅₀ = 5 µM for recombinant PDK1). It displays anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase(PI3K)/Akt pathway. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 µM across a panel of 60 cancer cell lines.
Category Biochemicals
Molecular formula C₂₆H₁₉F₃N₄O
Is it cell-permeable? Yes
Molecular weight 460.45
Storage condition -20 ̊C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence No
Is this a salt? No
CAS number 742112-33-0
Storage instructions Protect from air and light
Maximum time for storage 36 months
Physical appearance White to off-white solid
Reconstitute instructions DMSO (>10 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Short name OSU-03012 for activation
Technique activation
Alternative name OSU-03012 to measure cellular activation
Tissue cell
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