Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
White to off-white solid
Is this a salt?
Is it cell-permeable?
≥99% by TLC
DMSO (~200 mg/ml) or Ethanol (~40 mg/ml)
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
RO 20-1724 for activation
RO 20-1724 to measure cellular activation
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