Human CellExp™ Gremlin / GREM1, Fc Tag, Human recombinant

  • Catalog number
    P1123-10
  • Price
    Please ask
  • Size
    10 ug
  • Synonyms
    GREM1, CKTSF1B1, DAND2, DRM, PIG2
  • Alternative_names
    GREM1, CKTSF1B1, DAND2, DRM, PIG2
  • Description
    A TGF-β antagonist
  • Recombinant
    Yes
  • Source
    HEK 293 cells
  • Purity by SDS PAGE
    > 95%
  • Assay
    SDS-PAGE
  • Endotoxin Level
    < 1.0 EU per/ug
  • Activity Specifications test method
    Measured by its binding ability in a functional ELISA.
  • Biological activity
    Immobilized Human BMP-2, at 2 ug/Ml (100 uL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.
  • Binding Capacity
    Immobilized Human BMP-2, at 2 ug/Ml (100 uL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.
  • Molecular Weight
    44.2 kDa
  • Storage Temp
    -20°C
  • Shipping
    Gel Pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized
  • Physical form description
    Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
  • Reconstitution Instructions
    Reconstitute in sterile deionized water to the desired protein concentration.
  • Background Information
    Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    CellExp™   Gremlin   GREM1   Tag  
  • Gene symbol
    GREM1-AS1, GREM1
  • Short name
    CellExp™ Gremlin / GREM1, Fc Tag, recombinant
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Label
    Fc Tag
  • Species
    Humans
  • Alternative name
    H. sapiens CellExp™ Gremlin / gremlin 1, fragment c detection labelled, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    gremlin 1, GREM1 and IDBG-5193 and ENSG00000166923 and 26585, receptor a this GO nist activity, Extracellular, Grem1 and IDBG-197200 and ENSMUSG00000074934 and 23892, GREM1 and IDBG-648566 and ENSBTAG00000046604 and 539079
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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