FAK2/PYK2B, Human Recombinant

• Catalog number
  P1416-50
• Price
  Please ask
• Size
  50 µg

• Synonyms
  PTK2B, CAK beta, Protein-tyrosine kinase 2-beta
• Alternative_names
  PTK2B, CAK beta, Protein-tyrosine kinase 2-beta
• Description
  Protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion.
• Recombinant
  False
• Source
  Baculovirus (sf9 Insect Cells)
• Purity by SDS PAGE
  >95%
• Assay
  SDS-PAGE
• Activity Specifications test method
  >20 U/ug (nmol/min/ug) measured by using BioVision ADPsensor™ Universal Kinase Activity Assay Kit K212-100
• Molecular Weight
  76.2 kDa (contains N-His tag).
• Storage Temp
  -80ºC
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Appearance
  Liquid
• Background Information
  FAK2 is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. It regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. The protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity
• Amino acid sequence
  aa 360-1009
• Handling
  Centrifuge the vial prior to opening.
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  FAK2/PYK2B  
• Gene symbol
  PTK2B
• Short name
  FAK2/PYK2B, Recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  FAK2/PYK2B, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:9612
• Gene
  PTK2B
• Long gene name
  protein tyrosine kinase 2 beta
• Synonyms gene
  • FAK2
• Synonyms gene name
  • FAK2
• Synonyms
  • CAKB
  • PYK2
  • RAFTK
  • PTK
  • CADTK
• GenBank acession
  • U33284
• Locus
  8p21.2
• Discovery year
  1998-06-22
• Entrez gene record
  2185
• Pubmed identfication
  • 7544443
  • 7499242
• RefSeq identity
  • NM_004103
• Classification
  • MicroRNA protein coding host genes
  • Minor histocompatibility antigens
  • FERM domain containing
  • PTK2 family tyrosine kinases
• VEGA ID
  OTTHUMG00000102082

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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