Recombinant Down Regulator Of Transcription 1, TBP Binding (DR1)

Verified reactivity

Homo sapiens (Human)
Protein number

Q01658
Gene number

Please refer to GenBank
Other name

NC2; NC2-BETA; Negative Cofactor 2; TATA-binding protein-associated phosphoprotein
Protein origin

E.coli
Protein region

Please contact us.
Protein sequence

Please contact us.
Information about sequence

Ala2~Glu170
Expected molecular weight

22.2kDa
Protein purity

≥ 95%
Verified applications

SDS-PAGE; WB; ELISA; IP.
Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.
Use before

1 year
Shipping requirements

Blue ice
Estimated production time

7-11 business days
Notes

For research use only. Not for diagnostic procedures.
Hyperlink
Source

Recombinants or rec. proteins
Group

recombinants
Description

The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.

Gene target

Down Regulator Transcription TBP Binding DR1
Gene symbol

TBP, DR1, CHRFAM7A, PSMC3, PSMC4
Short name

Recombinant Down Regulator Of Transcription 1, TBP Binding (DR1)
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. bioma advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Label

two N-terminal Tags, His-tag and T7-tag
Alternative name

Rec. Down Regulator on Transcription 1, TBP Binding (DR1)
Alternative technique

rec

Identity

HGNC:11588
Gene

TBP
Long gene name

TATA-box binding protein
Synonyms gene
- GTF2D1
- SCA17
Synonyms
- TFIID
GenBank acession
- M55654
Locus

6q27
Discovery year

1993-05-26
Entrez gene record

6908
Pubmed identfication
- 2194289
- 11448935
RefSeq identity
- NM_003194
Classification
- General transcription factor IID complex subunits
- General transcription factor IIIB complex subunits
- General transcription factors
VEGA ID

OTTHUMG00000016084

Identity

HGNC:3017
Gene

DR1
Long gene name

down-regulator of transcription 1
Synonyms gene name
- down-regulator of transcription 1, TBP-binding (negative cofactor 2)
Synonyms
- NC2-BETA
- NC2B
- NCB2
Synonyms name
- negative cofactor 2
- negative cofactor 2 beta
GenBank acession
- M97388
Locus

1p22.1
Discovery year

1996-07-11
Entrez gene record

1810
Pubmed identfication
- 1339312
- 9040789
RefSeq identity
- NM_001938
Classification
- ATAC complex
VEGA ID

OTTHUMG00000010862

Identity

HGNC:15781
Gene

CHRFAM7A
Long gene name

CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
Synonyms gene name
- CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Synonyms
- D-10
- CHRNA7-DR1
GenBank acession
- AF029838
Locus

15q13.2
Discovery year

2001-06-29
Entrez gene record

89832
Pubmed identfication
- 11829490
RefSeq identity
- NM_148911
VEGA ID

OTTHUMG00000175645

Name

Gene Knockdown Techniques
Concept

Scope note: The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.
Tree numbers
- E05.393.335.500
Qualifiers

ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data