PINX1 Antibody

• Catalog number
  R32303
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PINX1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the PINX1 antibody should be determined by the researcher.
• Intented use
  This PINX1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q96BK5
• Purity
  Antigen affinity
• Description
  PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.
• Immunogen
  Amino acids DHIKVQVKNNHLGLGATINNEDNWIAHQDD of human PINX1 were used as the immunogen for the PINX1 antibody.
• Storage
  After reconstitution, the PINX1 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PINX1  
• Gene symbol
  PINX1-DT, PINX1
• Short name
  Anti-PINX1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to PINX1
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:55532
• Gene
  PINX1-DT
• Long gene name
  PINX1 divergent transcript
• Locus
  8p23.1
• Discovery year
  2021-03-22
• Entrez gene record
  101929229
• RefSeq identity
  • NR_125432
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:30046
• Gene
  PINX1
• Long gene name
  PIN2 (TERF1) interacting telomerase inhibitor 1
• Synonyms gene name
  • PIN2/TERF1 interacting telomerase inhibitor 1
• Synonyms
  • LPTL
  • LPTS
  • FLJ20565
  • MGC8850
  • Gno1
  • Pxr1
• Synonyms name
  • PIN2 interacting protein 1
  • liver-related putative tumor suppressor
• GenBank acession
  • AF418553
• Locus
  8p23.1
• Discovery year
  2010-04-26
• Entrez gene record
  54984
• Pubmed identfication
  • 11003615
  • 11701125
• RefSeq identity
  • NM_017884
• Classification
  • G-patch domain containing
  • SSU processome
  • MicroRNA protein coding host genes

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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