Caspase (ICE-Family) Inhibitor, Cell Culture, 2mM, (Z-VAD-FMK)

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Description

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. For cells, cell lines and tissues in culture till half confluency. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

Caspase ICE-Family Inhibitor Culture 2mM Z-VAD-FMK
Gene symbol

CASP1, CASP5, CES2, CARD18, CARD16, CASP4, CASP9, CASP7, PSMB7, PLA2G4F
Short name

Caspase (ICE-Family) Inhibitor, Culture, 2mM, (Z-VAD-FMK)
Technique

culture
Alternative name

caspase (ICE-family) suppressor, cellular Culture, 2mM, (Z-VAD-FMK)
Tissue

cell

Identity

HGNC:1499
Gene

CASP1
Long gene name

caspase 1
Synonyms gene
- IL1BC
Synonyms gene name
- caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
- caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- caspase 1, apoptosis-related cysteine peptidase
Synonyms
- ICE
Synonyms name
- caspase-1
- interleukin 1, beta, convertase
GenBank acession
- U13697
Locus

11q22.3
Discovery year

1992-05-07
Entrez gene record

834
Pubmed identfication
- 1373520
- 9250871
RefSeq identity
- NM_033292
Classification
- Caspases
- Caspase recruitment domain containing
VEGA ID

OTTHUMG00000048072

Identity

HGNC:1506
Gene

CASP5
Long gene name

caspase 5
Synonyms gene name
- caspase 5, apoptosis-related cysteine protease
- caspase 5, apoptosis-related cysteine peptidase
Synonyms
- ICE(rel)III
Locus

11q22.3
Discovery year

1996-09-13
Entrez gene record

838
Pubmed identfication
- 7797592
- 9250871
RefSeq identity
- NM_004347
Classification
- Caspases
- Caspase recruitment domain containing
VEGA ID

OTTHUMG00000048073

Identity

HGNC:1505
Gene

CASP4
Long gene name

caspase 4
Synonyms gene name
- caspase 4, apoptosis-related cysteine protease
- caspase 4, apoptosis-related cysteine peptidase
Synonyms
- ICE(rel)II
- ICH-2
- TX
GenBank acession
- U25804
Locus

11q22.3
Discovery year

1996-07-22
Entrez gene record

837
Pubmed identfication
- 7797510
- 9250871
RefSeq identity
- NM_001225
Classification
- Caspases
- Caspase recruitment domain containing
VEGA ID

OTTHUMG00000166078

Identity

HGNC:1511
Gene

CASP9
Long gene name

caspase 9
Synonyms gene name
- caspase 9, apoptosis-related cysteine protease
- caspase 9, apoptosis-related cysteine peptidase
Synonyms
- MCH6
- ICE-LAP6
- APAF-3
- PPP1R56
Synonyms name
- protein phosphatase 1, regulatory subunit 56
GenBank acession
- U60521
Locus

1p36.21
Discovery year

1996-11-11
Entrez gene record

842
Pubmed identfication
- 8663294
- 9390557
RefSeq identity
- NM_032996
Classification
- Caspases
- Apoptosome
- Caspase recruitment domain containing
- Protein phosphatase 1 regulatory subunits
VEGA ID

OTTHUMG00000002256

Identity

HGNC:1508
Gene

CASP7
Long gene name

caspase 7
Synonyms gene name
- caspase 7, apoptosis-related cysteine protease
- caspase 7, apoptosis-related cysteine peptidase
Synonyms
- MCH3
- CMH-1
- ICE-LAP3
GenBank acession
- U37448
Locus

10q25.3
Discovery year

1996-07-22
Entrez gene record

840
Pubmed identfication
- 8521391
- 8576161
RefSeq identity
- NM_033338
Classification
- Caspases
VEGA ID

OTTHUMG00000019076

Identity

HGNC:9544
Gene

PSMB7
Long gene name

proteasome 20S subunit beta 7
Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 7
- proteasome subunit beta 7
Synonyms
- Z
Synonyms name
- proteasome subunit β2
GenBank acession
- AJ420455
Locus

9q33.3
Discovery year

1995-11-22
Entrez gene record

5695
Pubmed identfication
- 8811196
RefSeq identity
- NM_002799
Classification
- Proteasome
VEGA ID

OTTHUMG00000021042

Name

Models, Chemical
Concept

Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Tree numbers
- E05.599.495